post-title portfolio-title Pemetrexed for Injection 500mg (Actoforan) 2023-07-08 10:47:10 no no

GENERIC NAME OF THE MEDICINAL PRODUCT:

a) Pemetrexed for Injection USP 100mg
b) Pemetrexed for Injection USP 500mg
c) Pemetrexed for Injection USP 1gm

QUALITATIVE AND QUANTITATIVE COMPOSITION:

a) Pemetrexed for Injection USP 100mg
Each vial contains:
Pemetrexed disodium
Equivalent to Pemetrexed…….100mg
Mannitol USP ……………………….106mg
Hydrochloric acid NF and/or Sodium hydroxide NF may have been added to adjust pH

b) Pemetrexed for Injection USP 500mg
Each vial contains:
Pemetrexed disodium
Equivalent to Pemetrexed…….500mg
Mannitol USP ……………………….500mg
Hydrochloric acid NF and/or Sodium hydroxide NF may have been added to adjust pH

c) Pemetrexed for Injection USP 1000mg
Each vial contains:
Pemetrexed disodium
Equivalent to Pemetrexed…….1000mg
Mannitol USP ……………………….1000mg
Hydrochloric acid NF and/or Sodium hydroxide NF may have been added to adjust pH

THERAPEUTIC INDICATION:

Pemetrexed is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer.

DIRECTION OF USE:

For Intravenous infusion only.
Reconstitution for 500mg: Reconstitute the vial with 20ml of 0.9% Sodium Chloride Injection. Reconstituted solution must be further diluted before use (see accompanying literature).
Administer Infusion solution within in 24 hours after initial reconstitution. Discard unused portion.
Read accompanying package insert for detailed dosage, directions for use and precautions.

CAUTION & WARNING:

CAUTION: This injection should not be used if it contains visible particulate matter after reconstitution.
WARNING: Cytotoxic Agent: To be sold by retail on the prescription of an Oncologist/ Cancer Hospital only.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.
Discard Unused portion.
Keep out of the reach of the children.

STORAGE & DOSAGE:

Storage: Store vials at 20°C to 25°C (68° to 77° F); excursions permitted between 15°C to 30°C (59° to 86° F) [See USP Controlled Room Temperature]. Protected from light
Dosage: As directed by an Oncologist.

Pemetrexed for Injection 500mg (Actoforan) Technical Specification:

Product Name:Pemetrexed for Injection 500mg
Brand Name:Actoforan
Strength:100mg, 500mg, 1gm
Dosage Form:Lyophilized
Dry Powder for Injection
Packing:SINGLE USE VIAL
Route of Administration:For I.V. infusion only.
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Anti-Cancer
Indication: Pemetrexed Injection is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed is used in combination with other chemotherapy medications as first treatment for non-small cell lung cancer (NSCLC).
Storage:Store vials at 20°C to 25°C (68° to 77° F); excursions permitted between 15°C to 30°C (59° to 86° F) [See USP Controlled Room Temperature]. Protected from light

India’s Leading Manufactures of Pemetrexed Injection:

The healthcare industry in India has seen tremendous growth in recent years, with the country becoming a major hub for anticancer pharmaceutical manufacturing. One crucial aspect of this growth has been the production of high-quality anticancer, with Pemetrexed Injection 500mg Manufacturers in India playing a significant role. As a manufacturer, we are renowned for producing a range of molecules, including antibiotics, antifungals, anti-cancer drugs, and many others. Pemetrexed is an important anticancer; it is used in combination with other chemotherapy medications as the first treatment for non-small cell lung cancer (NSCLC). Pemetrexed Injection Manufacturers in India adhere to strict quality standards, ensuring that their products are safe and effective for patients. In this article, we will delve deeper into the world of Pemetrexed Injection Manufacturers in India and explore the range of molecules they produce, highlighting their importance in the healthcare industry.

Pemetrexed Injection Exporters in India Injection 1gm Manufacturers, Suppliers in India:

Taj Pharmaceuticals is of the prominent Pemetrexed for injection 500mg Manufacturers in India, bringing the best quality products. Our company Taj Pharma has rich experience in the niche manufacturing of Pemetrexed Injection.

Taj Pharmaceuticals is a reputed Manufacturer & Supplier of Pemetrexed Injection in India prefer Taj Pharma is best known for the topmost standards and consistent quality of its products.

Taj Pharma is a well-known Pemetrexed Injection 500mg Manufacturer in India that assures high- quality and high standards. Strict quality control ensures that every batch of medicine brings a harmonious standard.

Pemetrexed Injection manufactured at Taj Pharma follows ICH; i.e., the product is manufactured to comply with BP quality standards, considered the Best in the world. Further, Taj Pharma uses Pemetrexed for Injection grade best active ingredient to manufacture its Injections to comply with international standards of European products.

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Pemetrexed for Injection 500mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Pemetrexed for Injection 500mg
    Each vial contains:
    Pemetrexed disodium
    Equivalent to Pemetrexed…….500mg
    Mannitol USP ……………………….500mg
    Hydrochloric acid NF and/or Sodium hydroxide NF may have been added to adjust pH

THERAPEUTIC INDICATION:

Pemetrexed Injection is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed injection is used in combination with other chemotherapy medications as a first treatment for a certain type of non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body

DIRECTION OF USE:

For Intravenous infusion only.

Reconstitution for 500mg: Reconstitute the vial with 20ml of 0.9% Sodium Chloride Injection. Reconstituted solution must be further diluted before use (see accompanying literature).

Administer Infusion solution within 24 hours after initial reconstitution. Discard unused portion.

Read accompanying package insert for detailed dosage, directions for use and precautions.

CAUTION & WARNING:

CAUTION: This injection should not be used if it contains visible particulate matter after reconstitution.

WARNING: Cytotoxic Agent: To be sold by retail on the prescription of an Oncologist/ Cancer Hospital only.

FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.

Discard Unused portion.

Keep out of the reach of the children.

STORAGE & DOSAGE:

Storage: Store vials at 20°C to 25°C (68° to 77° F); excursions permitted between 15°C to 30°C (59° to 86° F) [See USP Controlled Room Temperature]. Protected from light

Dosage: As directed by an Oncologist.

Why Taj Pharmaceuticals?

The Leading Choice for Pemetrexed for Injection: Taj Pharma’s Commitment to Quality and Patient Care. When it comes to Pemetrexed for Injection, Taj Pharma stands as a renowned name you can trust. Our commitment to quality, affordability, and patient well-being sets us apart. With years of pharmaceutical expertise, we’ve earned the confidence of healthcare professionals and patients worldwide.

Why choose Taj Pharma for Pemetrexed for Injection?

  • Uncompromising Quality: We adhere to the highest quality standards, ensuring that every dose of Pemetrexed meets rigorous quality control measures. Your health is our top priority.
  • Affordability: Access to life-saving medications should never be out of reach. Taj Pharma offers competitive pricing, making Pemetrexed for Injection more accessible for those in need.
  • Comprehensive Support: Our dedicated customer support team is here to assist you with any questions or concerns you may have. We understand the challenges you face and are committed to providing solutions.
  • Proven Track Record: Taj Pharma has a history of delivering safe and effective pharmaceuticals. Trust in our experience and proven results.

Explore our range of Pemetrexed for Injection products and experience the Taj Pharma difference. Choose reliability for your healthcare needs and put your trust in a name that’s synonymous with excellence. Taj Pharma and their offerings but also provides potential customers with valuable information about the company’s strengths, which can help in their decision-making process.

What is Pemetrexed for Injection and its use?

Pemetrexed for Injection is a medication used in cancer treatment. It is the generic name for a drug that is often marketed under brand names like Alimta. Pemetrexed is a type of chemotherapy drug that falls under the category of antifolate agents. It works by inhibiting certain enzymes that are necessary for the growth and replication of cancer cells.

Pemetrexed is primarily used to treat the following types of cancer:

  • Non-Small Cell Lung Cancer (NSCLC): Pemetrexed, often in combination with other chemotherapy drugs, is used in the treatment of advanced or metastatic non-small cell lung cancer, a common type of lung cancer.
  • Malignant Pleural Mesothelioma: It is also approved for the treatment of malignant pleural mesothelioma, a rare but aggressive form of cancer that affects the lining of the lungs.

Pemetrexed is usually administered intravenously (through a vein) by a healthcare professional, as an infusion. The specific dosage and treatment plan will depend on the type and stage of cancer, as well as the patient’s overall health and response to the medication. Treatment with Pemetrexed is typically part of a larger treatment regimen that may include other chemotherapy drugs or supportive therapies.

It’s important to note that Pemetrexed can have side effects, including nausea, fatigue, decreased blood cell counts, and skin reactions. Patients receiving this treatment should discuss the potential side effects and their management with their healthcare provider. Pemetrexed is a powerful medication, and its use should be under the supervision of a qualified oncologist who can assess the individual patient’s condition and determine the most appropriate treatment plan.

How does Pemetrexed for Injection Work?

Pemetrexed for Injection works by interfering with the growth and replication of cancer cells, primarily through its action on the folate metabolic pathway. Here’s a simplified explanation of how it works:

  • Folate Metabolism: Cancer cells, like all cells, need folate (a type of vitamin B9) for their growth and division. Folate is essential for the synthesis of DNA, RNA, and other molecules necessary for cell replication.
  • Inhibition of Key Enzymes: Pemetrexed is an antifolate agent. It inhibits several enzymes involved in the folate metabolic pathway, including dihydrofolate reductase (DHFR), thymidylate synthase (TS), and glycinamide ribonucleotide formyltransferase (GARFT).
  • DNA and RNA Synthesis Blockage: By inhibiting these enzymes, Pemetrexed disrupts the synthesis of DNA and RNA, crucial components for the replication of cancer cells.
  • Cell Growth Inhibition: With impaired DNA and RNA synthesis, cancer cells can’t replicate effectively, and their growth is slowed or halted. This can lead to cancer cell death or make them more susceptible to the effects of other chemotherapy drugs.
  • Selective Action: Pemetrexed tends to have a more significant impact on rapidly dividing cells, such as cancer cells, compared to normal, healthy cells. This selectivity is what makes it an effective chemotherapy agent.

Pemetrexed is often used in combination with other chemotherapy drugs or targeted therapies to enhance its effectiveness in treating cancer. The specific treatment regimen and dosages are determined by an oncologist based on the type and stage of cancer, as well as the patient’s individual health and response to treatment. While Pemetrexed can be effective in slowing the growth of cancer cells, it may also affect normal, healthy cells, leading to various side effects. Careful monitoring and supportive care are essential when using this medication to manage these side effects and ensure the best possible outcome for the patient.

Benefits of Pemetrexed for Injection:

  • Effective Cancer Treatment: Pemetrexed is used in the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma, where it can be effective in slowing down the growth and spread of cancer cells.
  • Selective Action: Pemetrexed tends to affect rapidly dividing cells, like cancer cells, more than normal, healthy cells. This selectivity helps in targeting cancer while minimizing damage to healthy tissues.
  • Combination Therapy: It is often used in combination with other chemotherapy drugs or targeted therapies to enhance its effectiveness in treating cancer. Combination regimens can offer better treatment outcomes in some cases.
  • Control of Symptoms: Pemetrexed can help control cancer-related symptoms and improve the quality of life for cancer patients.

Side Effects of Pemetrexed for Injection:

  • Nausea and Vomiting: This is a common side effect. Anti-nausea medications are often prescribed to manage this.
  • Fatigue: Many people experience fatigue during treatment. It’s essential to get plenty of rest and conserve energy.
  • Decreased Blood Cell Counts: Pemetrexed can cause a decrease in red blood cells (anemia), white blood cells (neutropenia), and platelets (thrombocytopenia). This may lead to increased risk of infection, fatigue, and a tendency to bleed or bruise more easily.
  • Skin Reactions: Skin rashes and sensitivity to sunlight can occur. It’s crucial to protect the skin from sun exposure during treatment.
  • Mouth Sores: Some people may develop mouth sores or ulcers.
  • Kidney Function: Pemetrexed can affect kidney function, so kidney function is monitored during treatment.
  • Liver Function: It can also affect liver function, and regular liver function tests are typically conducted.
  • Hair Loss: Hair thinning or loss is a potential side effect, but not everyone experiences this.
  • Digestive Issues: Diarrhea or constipation may occur.
  • Pulmonary Toxicity: In some cases, Pemetrexed can cause lung problems, so patients should be monitored for any respiratory symptoms.

It’s essential for patients receiving Pemetrexed to discuss potential side effects with their healthcare team and to have a plan in place for managing these side effects. Supportive care and medications can often help alleviate discomfort and allow patients to continue treatment. The benefits and risks of using Pemetrexed should be carefully evaluated in the context of an individual’s cancer diagnosis and overall health. Patients should consult with their oncologist to make informed decisions about their treatment.

Frequently asked questions (FAQs) about Pemetrexed for Injection:

  1. What is Pemetrexed for Injection?

Pemetrexed for Injection is a chemotherapy medication used in the treatment of certain types of cancer, such as nonsmall cell lung cancer (NSCLC) and malignant pleural mesothelioma.

  1. How does Pemetrexed work?

Pemetrexed inhibits key enzymes in the folate metabolic pathway, disrupting DNA and RNA synthesis in cancer cells and inhibiting their growth.

  1. What types of cancer is Pemetrexed used to treat?

Pemetrexed is primarily used to treat NSCLC and malignant pleural mesothelioma.

  1. Is Pemetrexed used alone or in combination with other drugs?

Pemetrexed is often used in combination with other chemotherapy drugs or targeted therapies to enhance its effectiveness.

  1. What are the potential benefits of Pemetrexed treatment?

Benefits include effective cancer treatment, selective action on cancer cells, symptom control, and the potential for combination therapy.

  1. What are the common side effects of Pemetrexed?

Common side effects include nausea, fatigue, decreased blood cell counts, skin reactions, mouth sores, hair loss, digestive issues, and more. Regular monitoring is essential.

  1. Is hair loss a common side effect of Pemetrexed?

Hair thinning or loss can occur, but it doesn’t affect everyone.

  1. Can Pemetrexed cause kidney or liver problems?

Pemetrexed can affect kidney and liver function, so regular monitoring of these functions is typically conducted.

  1. Is there a risk of lung problems with Pemetrexed?

In some cases, Pemetrexed can cause lung problems, so patients should be monitored for any respiratory symptoms.

  1. What precautions should I take while on Pemetrexed treatment?

Protecting the skin from sun exposure, monitoring for side effects, staying hydrated, and following the treatment plan as prescribed are important precautions.

  1. How is Pemetrexed administered?

Pemetrexed is typically administered intravenously (IV) by a healthcare professional in a clinical setting.

  1. What should I discuss with my oncologist before starting Pemetrexed treatment?

You should discuss your specific cancer diagnosis, treatment plan, potential side effects, and any other questions or concerns with your oncologist.

  1. Are there any potential drug interactions with Pemetrexed?

It’s important to inform your healthcare provider about all medications and supplements you are taking, as some drugs can interact with Pemetrexed.

  1. Can I continue with my normal activities during Pemetrexed treatment?

The impact on daily activities can vary from person to person, but it’s common to experience fatigue. You should discuss your specific circumstances with your healthcare team.

  1. Is Pemetrexed safe during pregnancy or breastfeeding?

Pemetrexed can harm an unborn baby, so it’s crucial to discuss pregnancy plans and breastfeeding with your healthcare provider.

As Pemetrexed for Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Pemetrexed for Injection product in Following Countries:

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Pemetrexed for Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Pemetrexed for Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274

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