A suppository is a solid dosage form that is inserted into the rectum, vagina, or urethra, where it dissolves or melts and exerts local or systemic effects. Suppositories are used to deliver medications that act both systemically and locally. A suppository is another way to deliver a drug. It’s a small, round or cone-shaped object that you put in your body, often into your bottom. Once it’s inside, it melts or dissolves and releases its medication. Suppositories may not be the most pleasant product you’ll ever use.