Enhancing Pharmaceuticals Through Advanced Tablet Coating Techniques

Top Film Coated Tablets Manufacturers & Suppliers in India
Top Film Coated Tablets Manufacturers

In the world of pharmaceuticals, tablets have become a widely accepted and convenient form of medication. However, not all tablets are created equal. Some undergo a unique process known as tablet coating, which can significantly impact their appearance, taste, stability, and ease of consumption. In this comprehensive guide, we delve into the world of pharmaceutical tablet coating, with a focus on Taj Pharmaceuticals’ state-of-the-art tablet coating facilities.

Tablet coating is a specialized process that involves applying a coating material to the surface of a tablet to achieve specific desired properties, which can vary from improved taste and odor to controlled release properties. These coatings serve both functional and aesthetic purposes, making the tablet not only more palatable for patients but also enhancing its overall quality.

Taj Pharma Plant: Equipped for Excellence

Taj Pharmaceuticals stands out in the pharmaceutical industry for its commitment to quality and innovation. The company’s tablet coating capabilities are truly cutting-edge, featuring Ultra Modern Auto Coater machines in various sizes, including 48-inch, 42-inch, and two 36-inch machines. These state-of-the-art machines offer a range of features that ensure the highest quality tablet coatings.

Our Auto Coater Machine Features

  1. Automatic Tablet Coater Exporters: Taj Pharmaceuticals ensures that their tablet coating process is fully automated, adhering to cGMP guidelines for pharmaceutical manufacturing.
  2. Modular Design: The machines are designed for flexibility and ease of maintenance, with modules that can be quickly accessed and serviced.
  3. Accurate Batch Consistency: Taj Pharmaceuticals prides itself on producing tablets with consistent coating quality, thanks to precise spraying using special design anti-bearding type guns.
  4. In-built WIP System: The integrated Work-In-Progress system allows for real-time monitoring and control during the coating process.
  5. Quick Accessibility for Maintenance & Cleaning: Downtime is minimized with easy access for maintenance and cleaning, ensuring continuous production.
  6. Quick-release of Plenums: The design allows for quick release and cleaning of pan and plenums, further improving efficiency.
  7. Effective Sealing of Doors: Ensuring a sealed environment is crucial in pharmaceutical manufacturing, and Taj Pharmaceuticals takes this seriously.
  8. Fully Automatic Operation through PLC: Programmable Logic Controllers guarantee precise control of the tablet coating process.
  9. Sugar Coating System (Optional): For tablets requiring sugar coating, Taj Pharmaceuticals offers this optional feature.
  10. Interchangeable Pans: The flexibility to use interchangeable pans up to ci 900 models provides versatility in tablet coating.
  11. Flameproof Construction: Safety is paramount, and the flameproof construction ensures a secure working environment.

Advantages of Tablet Coating

The advantages of tablet coating are multifaceted, making it a crucial step in pharmaceutical manufacturing. Here are some key benefits:

  • Improving Taste, Odor, and Color: Coatings can mask unpleasant tastes and odors, making medications more palatable. They can also enhance the tablet’s appearance.
  • Ease of Swallowing: For patients who struggle with swallowing pills, coated tablets can make the process much easier.
  • Product Stability: Coatings can protect the tablet’s active ingredients from environmental factors, such as humidity and oxygen, enhancing stability.
  • Protection Against Gastric Environment: Some medications need protection from the stomach’s acidic environment, and coatings can provide this safeguard.
  • Mechanical Resistance: Coatings can improve the tablet’s resistance to mechanical stress during handling and packaging.
  • Modifying Release Properties: Different coatings can control the rate at which the medication is released, allowing for extended or immediate release, depending on the formulation.

The Three Main Processes for Tablet Coating

Tablet coating can be categorized into three main processes:

1. Sugar Coating

Sugar coating is a labor-intensive process with multiple steps, resulting in a tablet weight increase of up to 30%-50%. This method involves sealing, subcoating, smoothing, coloring, and polishing.

Sealing

The seal coat protects the tablet core from water penetration and enhances its stability. Shellac, cellulose acetate phthalate (CAP), polyvinylacetate phthalate (PVAP), hyroxylpropyl cellulose, hyroxypropyl methylcellulose (HPMC), and Zein are common sealing coat materials.

Subcoating

Subcoating rounds the tablet edges and increases tablet weight. Lamination and suspension processes are used for subcoating.

Smoothing

Smoothing smooths out rough subcoated surfaces and increases tablet bulk. Smoothing syrup typically consists of sugar solids and may include other additives.

Coloring

Coloring enhances tablet appearance and stability. Water-insoluble pigments have replaced water-soluble dyes for uniform tablet color.

Polishing

Polishing gives sugar-coated tablets their characteristic shine using wax mixtures.

2. Film Coating

Film coating is a single-stage process that deposits a thin polymer film (between 20 and 100 μm) on tablets. It’s favored for its efficiency and is used for tablets, gelatin capsules, and multiparticulate systems.

Commonly Used Film-Coating Materials
  • Polymers: Hydroxyproply methyl cellulose (HPMC), Methyl hydroxyethyl cellulose, Ethylcellulose, Povidone
  • Enteric-coating Polymers: Acrylate polymers (Eudragit L and Eudragit S), Hydroxypropyl methylcellulose phthalate (HPMCP), Polyvinylacetate phthalate (PVAP)
  • Solvents: Water, Methanol, Ethanol, Acetone
  • Plasticizers: Polyethylene glycols (PEG), Glycerol, Castor oil, Triacetin
  • Colorants/Opacifiers: Insoluble pigments, Titanium dioxide, Silicate
  • Miscellaneous Agents: Flavors, sweeteners, antioxidants, etc.
The Film-Coating Process

Film coating involves spraying a coating solution onto tablets in a pan coater, followed by immediate drying to create a thin, even film. Various methods and parameters impact the coating quality.

Pharmaceutical tablet coating is an integral part of drug formulation and manufacturing, offering numerous advantages to both manufacturers and patients. Taj Pharmaceuticals, with its state-of-the-art tablet coating facilities, exemplifies excellence in this field. Through sugar coating and film coating processes, tablets can be transformed to meet specific requirements, from enhancing taste to controlling drug release.

As the pharmaceutical industry continues to evolve, innovations like advanced tablet coating techniques play a pivotal role in improving medication quality and patient compliance. Taj Pharmaceuticals remains at the forefront of these advancements, ensuring that every tablet they produce meets the highest standards of quality.

In the ever-expanding world of pharmaceuticals, Taj Pharmaceuticals stands as a beacon of excellence, committed to enhancing the lives of patients through the art and science of tablet coating.

Frequently Asked Questions (FAQs)

1. What is the purpose of tablet coating?

Tablet coating serves various purposes, including improving taste, odor, and appearance, enhancing ease of swallowing, increasing product stability, protecting against the gastric environment, and modifying release properties.

2. How does sugar coating differ from film coating?

Sugar coating is a labor-intensive process that involves multiple steps and can increase tablet weight significantly. In contrast, film coating is a single-stage process that deposits a thin polymer film on tablets, offering efficiency and control.

3. What are some commonly used materials in tablet coating?

Common materials used in tablet coating include binders (acacia, gelatin, cellulose derivatives), fillers (calcium carbonate, titanium dioxide, talc), colorants (dyes, iron oxides, titanium dioxide), and antiadhesives (talc).

4. Why is tablet coating essential in pharmaceutical manufacturing?

Tablet coating is essential to enhance the quality and palatability of pharmaceutical tablets. It also plays a crucial role in ensuring stability, controlled release, and protection of the drug.

5. How does Taj Pharmaceuticals ensure quality in tablet coating?

Taj Pharmaceuticals utilizes state-of-the-art auto coater machines with advanced features and adheres to cGMP guidelines, ensuring accurate batch consistency and high production efficiency.

Explore Innovative Tablet Coating at Taj Pharmaceuticals

Visit Here: Taj Pharmaceuticals Tablet Coating