Pyrimethamine Tablets USP 25mg is a generic antiparasitic medication. Known for its efficacy against malaria and toxoplasmosis, this drug is crucial in combating parasitic infections. In this article, we will delve into the details of Pyrimethamine Tablets, covering its uses, mechanism of action, benefits, side effects, and more.

Pyrimethamine Tablet Manufacturers, Suppliers
Pyrimethamine Tablet

Pyrimethamine Tablets USP 25mg is a powerful medication used to treat and prevent parasitic infections. It works by inhibiting the growth and reproduction of parasites. This article will explore the technical specifications, therapeutic uses, and other vital information about Pyrimethamine Tablets.

Product Specifications

Generic Name: Pyrimethamine Tablets USP 25mg
Strength: 25mg
Dosage Form: Tablets (Uncoated)
Route of Administration: Oral
Packing: Available in packs of 10, 30, 100, and 500 tablets
Pack Insert/Leaflet: Includes PIL (Patient Information Leaflet) and SmPC (Summary of Product Characteristics)
Regulatory Documents: COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier

Therapeutic Uses and Indications

Pyrimethamine is used with other medications to treat serious parasitic infections like toxoplasmosis. It is also vital in malaria treatment and prevention.

Malaria Treatment

Pyrimethamine is essential in treating malaria, particularly infections caused by the Plasmodium falciparum parasite. It is often combined with other antimalarial drugs to increase effectiveness and reduce drug resistance.

Malaria Prophylaxis

For travelers and people in malaria-endemic regions, Pyrimethamine Tablets are prescribed to prevent malaria. They are typically used with other antimalarial medications.

Toxoplasmosis Treatment

Pyrimethamine treats toxoplasmosis, an infection that can affect the brain and eyes. Combined with sulfadiazine, it effectively reduces the severity of the infection and prevents complications.

Preventing Congenital Toxoplasmosis

Pregnant women at risk of toxoplasmosis may be prescribed Pyrimethamine to prevent transmission to the fetus.

Mechanism of Action

Pyrimethamine belongs to the antifolate class of drugs. It works by inhibiting the enzyme dihydrofolate reductase (DHFR), essential for DNA and RNA synthesis in parasites.

Inhibition of Folate Metabolism

Pyrimethamine interferes with folate metabolism, which parasites need for growth and reproduction. This inhibition prevents parasites from synthesizing nucleotides, crippling their ability to replicate.

Synergistic Effects

Often used with sulfadoxine or sulfadiazine, Pyrimethamine creates synergistic effects, enhancing treatment efficacy and reducing resistance risk.

Benefits of Pyrimethamine Tablets

Effective Malaria Treatment

Pyrimethamine is a key component of antimalarial therapies, effectively treating severe and life-threatening malaria cases.

Malaria Prevention

As part of prophylactic treatment, Pyrimethamine reduces the risk of contracting malaria for travelers and residents in malaria-endemic areas.

Toxoplasmosis Management

It effectively treats toxoplasmosis, reducing infection severity and preventing complications.

Prevention of Congenital Toxoplasmosis

Prescribed to pregnant women, Pyrimethamine helps prevent fetal transmission of toxoplasmosis.

Side Effects of Pyrimethamine Tablets

While Pyrimethamine is effective, it may cause side effects. It’s crucial to use this medication under medical supervision.

Common Side Effects

  • Gastrointestinal upset (nausea, vomiting, diarrhea)
  • Mouth ulcers or sores
  • Skin rashes and itching

Serious Side Effects

  • Blood disorders (anemia, leukopenia)
  • Folate deficiency
  • Allergic reactions (swelling, difficulty breathing)
  • Neurological effects (headaches, dizziness)
  • Liver and kidney function issues

Drug Interactions

Pyrimethamine may interact with other medications. Inform your healthcare provider about all drugs you are taking.

Frequently Asked Questions

What is Pyrimethamine used for?

Pyrimethamine treats and prevents malaria and parasitic infections like toxoplasmosis.

How does Pyrimethamine work against malaria?

It inhibits the malaria parasite’s ability to synthesize DNA and RNA, essential for its survival.

Is Pyrimethamine used alone to treat malaria?

No, it is typically combined with other antimalarial drugs to enhance effectiveness and reduce resistance.

Can Pyrimethamine be used for malaria prevention?

Yes, it is used as a preventive measure for travelers and residents in malaria-endemic regions.

What is the role of Pyrimethamine in toxoplasmosis treatment?

It reduces the severity of toxoplasmosis and prevents complications when combined with sulfadiazine.

Are there any common side effects of Pyrimethamine Tablets?

Common side effects include gastrointestinal symptoms, mouth ulcers, and skin rashes.

Is Pyrimethamine safe during pregnancy?

It should be used with caution during pregnancy. Benefits and risks should be assessed by a healthcare provider.

Can Pyrimethamine cause allergies or severe reactions?

While rare, severe allergic reactions can occur. Seek immediate medical attention if you experience symptoms.

Is regular monitoring necessary while taking Pyrimethamine?

Yes, regular blood tests are required to monitor blood cell counts.

Can Pyrimethamine interact with other medications?

Yes, it can interact with other drugs. Inform your healthcare provider about all medications you are taking.

Is Pyrimethamine suitable for children?

Yes, it can be prescribed to children with adjusted dosage based on age and weight.

WHO-GMP Certified Pyrimethamine 25mg Tablets
Pyrimethamine 25mg Tablets

Pyrimethamine Tablets USP 25mg is a crucial medication in treating and preventing malaria and toxoplasmosis. Its effectiveness, when combined with other drugs, makes it a cornerstone in managing these parasitic infections. However, due to potential side effects and drug interactions, it should be used under medical supervision. By choosing high-quality Pyrimethamine from reputable manufacturers, you can ensure effective treatment and prevention of these serious health threats.