GENERIC NAME OF THE MEDICINAL PRODUCT:

A. Vecuronium Bromide for Injection 4mg
B. Vecuronium Bromide for Injection 10mg
C. Vecuronium Bromide for Injection 20mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

1. Vecuronium Bromide for Injection 4mg
Each ml contains:
Vecuronium Bromide USP…………………………………….1mg
Citric acid anhydrous, USP……………………………………2.075mg
Sodium Phosphate Dibasic
Anhydrous, USP……………………………………1.625mg
Mannitol, USP
(to adjust toxicity) ……………………………….9.7mg
May contain sodium hydroxide and/or phosphoric acid for pH adjustment.
pH 4(3.5 to 4.5)
This pack is also contains:
One FFS ampule of Sterile Water for Injection USP…….4ml

2. Vecuronium Bromide for Injection 10mg
Each ml contains:
Vecuronium Bromide USP…………………………………….1mg
Citric acid anhydrous, USP……………………………………2.075mg
Sodium Phosphate Dibasic
Anhydrous, USP……………………………………1.625mg
Mannitol, USP
(to adjust toxicity) ……………………………….9.7mg
May contain sodium hydroxide and/or phosphoric acid for pH adjustment.
pH 4(3.5 to 4.5)
This pack is also contains:
One FFS ampule of Sterile Water for Injection USP…….10ml


3. Vecuronium Bromide for Injection 20mg
Each ml contains:
Vecuronium Bromide USP…………………………………….1mg
Citric acid anhydrous, USP……………………………………2.075mg
Sodium Phosphate Dibasic
Anhydrous, USP……………………………………1.625mg
Mannitol, USP
(to adjust toxicity) ……………………………….9.7mg
May contain sodium hydroxide and/or phosphoric acid for pH adjustment.
pH 4(3.5 to 4.5)
This pack is also contains:
One FFS ampule of Sterile Water for Injection USP…….20ml

THERAPEUTIC INDICATIONS:

Vecuronium bromide is a peripherally acting, monoquarternary, steroidal, non-depolarizing neuromuscular blocker with an intermediate duration of action used during general anesthesia to facilitate endotracheal intubation, to aid in surgical relaxation, and, less commonly, in the intensive care setting to achieve paralysis to facilitate mechanical ventilation for adequately sedated patients.

PACKING:

4mg/4ml, 10mg/10ml, 20mg/20ml

DIRECTION OF USE:

• For Intravenous use only.
• Reconstitute to by adding Sterile Water for Injections USP and use immediately after preparation if it is clear.
For the detail of the Sterile Water for Injection refer the insert.
WHEN RECONSTITUTED WITH BACTERIOSTATIC WATER FOR INJECTION:
CONTAINS BENZYL ALCOHOL, WHICH IS NOT INTENDED FOR USE IN NEWBORNS. USE WITHIN 5 DAYS. MAY BE STORED AT ROOM TEMPERATURE OR REFRIGERATED.
WHEN RECONSTITUTED WITH STERILE WATER FOR INJECTION OR OTHER COMPATIBLE INTRAVENOUS SOLUTIONS:
REFRIGERATE VIAL. USE WITHIN 24 HOURS. SINGLE USE ONLY. DISCARD UNUSED PORTION.

CAUTION & WARNING:

CAUTION: The injection should not be used It contains visible particulate matter after reconstitution.
Discard unused portion within 24 hours of date prepared and time.
CONTAINS BENZYL ALCOHOL WHICH IS NOT FOR USE IN NEONATES.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.
WARNING: Not to be sold by retail without the prescription of a Registered Medical Practitioner.
Paralyzing Agent. Causes Respiratory Arrest. Facilities must be immediately available for artificial respiration.

STORAGE & DOSAGE:

Storage: Store dry powder at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).
Protect from light.
Retain in carton until time of use.
Keep all medicines out of reach of children.
Dosage: As directed by the Physician. For Deep Intramuscular Use.
NOTE:
1mg/ml when reconstituted.
Use within 5 days of date prepared and time. OR
Reconstituted with Sterile Water for Injection USP or other compatible IV solutions (see package inert) discard unused portion within 24 hours of date prepared and time.
Single use only.
The drug should be administered by adequately trained individuals familiar with its actions, characteristics, and hazards.

Vecuronium Bromide for Injection 10mg Technical Specification:

Product Name:Vecuronium Bromide for Injection 10mg
Brand Name:Generic
Strength:4mg, 10mg, 20mg
Dosage Form:Lyophilized Powder for Injection
Packing:1 Single use Vial/Ampoule + 1 WFI Tray
Route of Administration:For I.V. use only
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Neuromuscular Blockers
Indication: Vecuronium bromide is a peripherally acting, monoquarternary, steroidal, non-depolarizing neuromuscular blocker with an intermediate duration of action used during general anesthesia to facilitate endotracheal intubation, to aid in surgical relaxation, and, less commonly, in the intensive care setting to achieve paralysis to facilitate mechanical ventilation for adequately sedated patients.
Storage:Store dry powder at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from light. Retain in carton until time of use.

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Vecuronium Bromide for Injection 10mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Vecuronium Bromide for Injection 10mg
    Each ml contains:
    Vecuronium Bromide USP…………………………………….1mg
    Citric acid anhydrous, USP……………………………………2.075mg
    Sodium Phosphate Dibasic
    Anhydrous, USP……………………………………1.625mg
    Mannitol, USP
    (to adjust toxicity) ……………………………….9.7mg
    May contain sodium hydroxide and/or phosphoric acid for pH adjustment.
    pH 4(3.5 to 4.5)
    This pack is also contains:
    One FFS ampule of Sterile Water for Injection USP…….10ml

THERAPEUTIC INDICATIONS:

Vecuronium bromide is a peripherally acting, monoquarternary, steroidal, non-depolarizing neuromuscular blocker with an intermediate duration of action used during general anesthesia to facilitate endotracheal intubation, to aid in surgical relaxation, and, less commonly, in the intensive care setting to achieve paralysis to facilitate mechanical ventilation for adequately sedated patients.

PACKING:

4mg/4ml, 10mg/10ml, 20mg/20ml

DIRECTION OF USE:

  • For Intravenous use only.
  • Reconstitute to by adding Sterile Water for Injections USP and use immediately after preparation if it is clear.
    For the detail of the Sterile Water for Injection refer the insert.

When reconstituted with bacteriostatic water for injection: CONTAINS BENZYL ALCOHOL, WHICH IS NOT INTENDED FOR USE IN NEWBORNS. Use within 5 days. May be stored at room temperature or refrigerated.

When reconstituted with sterile water for injection or other compatible intravenous solutions: Refrigerate vial. Use within 24 hours. Single use only. Discard unused portion.

CAUTION & Warning:

CAUTION: The injection should not be used It contains visible particulate matter after reconstitution.

Discard unused portion within 24 hours of date prepared and time.

CONTAINS BENZYL ALCOHOL WHICH IS NOT FOR USE IN NEONATES.

FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.

Warning: Not to be sold by retail without the prescription of a Registered Medical Practitioner.

Paralyzing Agent. Causes Respiratory Arrest. Facilities must be immediately available for artificial respiration.

STORAGE & DOSAGE:

Storage: Store dry powder at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).
Protect from light.
Retain in carton until time of use.

Keep all medicines out of reach of children.

Dosage: As directed by the Physician. For Deep Intramuscular Use.

NOTE:
1mg/ml when reconstituted.

Use within 5 days of date prepared and time. OR
Reconstituted with Sterile Water for Injection USP or other compatible IV solutions (see package inert) discard unused portion within 24 hours of date prepared and time.

Single use only.

The drug should be administered by adequately trained individuals familiar with its actions, characteristics, and hazards.

Why Taj Pharmaceuticals?

Explore the reasons why Taj Pharma stands out as the preferred supplier for Vecuronium Bromide for Injection. For decades, Taj Pharma has consistently delivered high-quality pharmaceutical products, earning the trust of healthcare providers globally. Our commitment to excellence starts with rigorous quality control measures that guarantee the safety and efficacy of every Vecuronium Bromide dose. Taj Pharma adheres to stringent manufacturing standards, ensuring that healthcare professionals can rely on our products for critical patient care. Beyond quality, Taj Pharma’s competitive pricing and efficient supply chain make Vecuronium Bromide for Injection more accessible to healthcare facilities, helping them provide the best possible care to their patients. Choose Taj Pharma for Vecuronium Bromide for Injection and experience the difference that comes with a legacy of pharmaceutical excellence and unwavering dedication to healthcare.

Taj Pharma is the trusted choice for Vecuronium Bromide for Injection. With a legacy of quality and commitment to healthcare, Taj Pharma ensures safety and efficacy in every dose, making it the preferred provider for healthcare professionals worldwide.

What is Vecuronium Bromide for Injection and its use?

Vecuronium bromide for injection is a medication that belongs to a class of drugs known as neuromuscular blocking agents or neuromuscular blockers. These drugs are used in anesthesia and critical care settings to induce muscle relaxation and temporary paralysis. Vecuronium bromide is commonly used in medical settings for several purposes:

  • Muscle Relaxation during Surgery: Vecuronium bromide is often administered during surgery to induce muscle relaxation. This is important because it helps the surgeon to perform procedures that require immobility or to improve surgical access.
  • Endotracheal Intubation: It can be used to facilitate endotracheal intubation, which is the insertion of a tube into the windpipe (trachea) to establish and maintain an airway during anesthesia or in emergency situations.
  • Mechanical Ventilation: Vecuronium can be used to assist with mechanical ventilation in patients who are unable to breathe on their own or need controlled ventilation.
  • ICU Sedation: In the intensive care unit (ICU), Vecuronium may be used to manage patients on mechanical ventilators to prevent them from fighting against the ventilator or to reduce oxygen consumption in critically ill patients.

Vecuronium works by blocking the transmission of nerve impulses to the muscles at the neuromuscular junction, leading to muscle relaxation and paralysis. It is typically administered intravenously by trained medical professionals. The effects of Vecuronium are reversible with drugs like neostigmine or sugammadex, which are used to reverse neuromuscular blockade once its therapeutic purpose is served. Vecuronium bromide should only be administered by healthcare professionals who are experienced in its use due to its potential for serious side effects, such as respiratory depression and cardiovascular effects. The dosage and administration of Vecuronium should be carefully monitored to ensure the safety and well-being of the patient.

How does Vecuronium Bromide for Injection Work?

Vecuronium bromide, like other neuromuscular blocking agents, works by interfering with the transmission of nerve impulses at the neuromuscular junction, which is the point where nerve cells (motor neurons) communicate with muscle cells. Here’s how Vecuronium bromide for injection works:

  • Normal Muscle Contraction: In a normally functioning neuromuscular junction, when a nerve impulse (action potential) reaches the end of a motor neuron, it triggers the release of a neurotransmitter called acetylcholine (ACh) into the synaptic cleft, which is the small gap between the motor neuron and the muscle cell.
  • Binding of Acetylcholine: Acetylcholine binds to receptors on the muscle cell membrane (sarcolemma) known as nicotinic acetylcholine receptors (nAChRs). This binding of acetylcholine to its receptors initiates a series of events that ultimately lead to muscle contraction.
  • Muscle Contraction: When acetylcholine binds to nAChRs, it opens ion channels, allowing the flow of ions across the muscle cell membrane. This ion movement leads to muscle cell depolarization and, subsequently, muscle contraction.
  • Vecuronium’s Mechanism: Vecuronium bromide interferes with this normal process. It competes with acetylcholine for binding to the nicotinic acetylcholine receptors but does not activate them. Instead, Vecuronium binds to these receptors and prevents acetylcholine from binding. As a result, the muscle cell cannot depolarize, and muscle contraction is inhibited.
  • Muscle Relaxation: When Vecuronium blocks the action of acetylcholine at the neuromuscular junction, it causes muscle relaxation and paralysis. This is particularly useful in surgical and critical care settings, where temporary muscle relaxation is required to facilitate procedures, endotracheal intubation, mechanical ventilation, or to prevent the patient from moving during surgery.
  • Reversal: The effects of Vecuronium bromide are reversible. After its therapeutic purpose is served, the neuromuscular blockade can be reversed using drugs like neostigmine or sugammadex. Neostigmine, for example, increases the levels of acetylcholine at the neuromuscular junction by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine. This allows acetylcholine to outcompete Vecuronium and restore normal neuromuscular function.

It’s important to emphasize that Vecuronium bromide should be administered and monitored by trained healthcare professionals, as improper use or dosing can lead to serious complications, including respiratory depression and cardiovascular effects, due to the paralysis it induces in muscles, including the diaphragm (responsible for breathing). The administration of Vecuronium must be carefully controlled to ensure patient safety during surgery or critical care.

Benefits and Side effects of Vecuronium Bromide for Injection:

Vecuronium bromide for injection is a medication used in medical settings for its specific benefits, primarily related to its ability to induce muscle relaxation and paralysis. However, like all medications, it can also have side effects. Here are the benefits and potential side effects of Vecuronium bromide:

Benefits:

  • Muscle Relaxation: Vecuronium bromide is primarily used to induce muscle relaxation and paralysis. This is beneficial during surgery and certain medical procedures because it allows the surgical team or healthcare providers to have better access to the surgical site and perform procedures more safely and effectively.
  • Facilitation of Intubation: It can facilitate endotracheal intubation, which is essential for establishing and maintaining an airway during anesthesia or in emergency situations. Muscle relaxation makes it easier to insert a breathing tube into the trachea.
  • Mechanical Ventilation: Vecuronium can assist with mechanical ventilation in patients who are unable to breathe on their own or need controlled ventilation. This is commonly required in critical care settings.
  • Reduced Movement: By inducing paralysis, Vecuronium prevents involuntary muscle movements, which can be crucial during surgery to prevent injuries or complications caused by patient movement.

Side Effects:

  • Respiratory Depression: One of the most significant potential side effects of Vecuronium bromide is respiratory depression. Since it paralyzes the muscles, including the diaphragm (responsible for breathing), it can lead to breathing difficulties. It is essential to closely monitor the patient’s ventilation and provide mechanical ventilation if necessary.
  • Cardiovascular Effects: Vecuronium can affect heart rate and blood pressure in some patients. It may cause changes in heart rate and blood pressure, which require careful monitoring, especially in patients with cardiovascular conditions.
  • Allergic Reactions: Like any medication, Vecuronium bromide can cause allergic reactions in some individuals. Symptoms may include skin rash, itching, swelling, or difficulty breathing. Immediate medical attention is required if an allergic reaction is suspected.
  • Prolonged Neuromuscular Blockade: In some cases, the effect of Vecuronium may last longer than desired, requiring the use of reversal agents like neostigmine or sugammadex to counteract its effects.
  • Muscle Weakness Post-Operatively: After surgery or medical procedures, patients who have received Vecuronium may experience muscle weakness or residual effects that can last for some time. This can temporarily affect mobility and strength.
  • Other Potential Side Effects: Vecuronium may also lead to other side effects, including nausea, vomiting, increased salivation, and changes in electrolyte levels.

It’s important to note that Vecuronium bromide should only be administered by healthcare professionals who are experienced in its use and monitoring. The dosage and administration must be carefully controlled to minimize the risk of adverse effects and ensure the patient’s safety. The decision to use Vecuronium should be based on a thorough assessment of the patient’s medical condition and the potential benefits of muscle relaxation and paralysis in the specific clinical situation.

Frequently asked questions (FAQs) about Vecuronium Bromide for Injection:

  1. What is Vecuronium Bromide for Injection used for?

Vecuronium bromide is used to induce muscle relaxation and temporary paralysis in medical settings, particularly during surgery, endotracheal intubation, and mechanical ventilation.

  1. How does Vecuronium Bromide work?

Vecuronium bromide works by blocking the transmission of nerve impulses at the neuromuscular junction, leading to muscle relaxation and paralysis.

  1. Is Vecuronium Bromide reversible?

Yes, the effects of Vecuronium bromide can be reversed using drugs like neostigmine or sugammadex, which help restore normal neuromuscular function.

  1. Who administers Vecuronium Bromide?

Vecuronium bromide is typically administered by trained healthcare professionals, such as anesthesiologists or critical care nurses, who have experience in its use and monitoring.

  1. What are the benefits of using Vecuronium Bromide?

The primary benefits include muscle relaxation for surgical procedures, facilitation of endotracheal intubation, and assistance with mechanical ventilation.

  1. What are the potential side effects of Vecuronium Bromide?

Common side effects may include respiratory depression, cardiovascular effects, allergic reactions, muscle weakness, and prolonged neuromuscular blockade.

  1. Is Vecuronium Bromide safe for everyone?

Vecuronium should be used with caution and under close supervision in patients with certain medical conditions, such as heart or lung disease. It is not suitable for everyone, and individualized assessment is necessary.

  1. How is Vecuronium Bromide dosed?

The dosage of Vecuronium bromide depends on factors like the patient’s age, weight, medical condition, and the specific procedure. It should be administered in a carefully controlled manner.

  1. What precautions should be taken when using Vecuronium Bromide?

Healthcare professionals must monitor the patient’s respiratory status, heart rate, and blood pressure closely when using Vecuronium. Adequate ventilation and emergency reversal agents should be readily available.

  1. Can Vecuronium Bromide interact with other medications?

Yes, Vecuronium bromide can interact with certain medications, such as anesthetics and muscle relaxants. It is important for healthcare providers to consider potential drug interactions when administering it.

  1. Is Vecuronium Bromide available for self administration or over the counter purchase?

No, Vecuronium bromide is a prescription medication that is only administered by healthcare professionals in clinical settings. It is not available for self administration or over thecounter purchase.

  1. Can Vecuronium Bromide be used during pregnancy or breastfeeding?

Its use during pregnancy and breastfeeding should be carefully considered, as it can potentially affect the fetus or infant. The risks and benefits should be discussed with a healthcare provider.

  1. Is Vecuronium Bromide addictive?

No, Vecuronium bromide is not addictive, as it does not affect the brain’s reward pathways. It is solely used for its muscle relaxant properties in medical settings.

As Vecuronium Bromide for Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Vecuronium Bromide for Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Vecuronium Bromide for Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Vecuronium Bromide for Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593