GENERIC NAME OF THE MEDICINAL PRODUCT:

A. Tirofiban Hydrochloride I.V. Injection (5mg/100ml or 50mcg/ml) (Aggrixtaj)
B. Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml or 50mcg/ml) (Aggrixtaj)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

A. Tirofiban Hydrochloride I.V. Injection (5mg/100ml or 50mcg/ml)
Composition:
Each 100 ml contains:
Tirofiban Hydrochloride
Eq. to Tirofiban……………………………5mg
Sodium Chloride BP……………………0.9%w/v
Water for Injection USP…………………q.s.

B. Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml or 50mcg/ml)
Composition:
Each 250 ml contains:
Tirofiban Hydrochloride
Eq. to Tirofiban……………………………12.5mg
Sodium Chloride BP……………………2.25%w/v
Water for Injection USP…………………q.s.


THERAPEUTIC INDICATIONS:

Tirofiban is indicated for the prevention of early myocardial infarction in adult patients presenting with acute coronary syndromes without ST elevation (NSTE-ACS) with the last episode of chest pain occurring within 12 hours and with ECG changes and/or elevated cardiac enzymes.
Also prevent blood clots which can cause heart attacks or other health problems associated with excessive clotting.

PACKING:

Strength Pack Size
5mg-- 100ml
12.5mg-- 250ml

DIRECTION OF USE:

To be used with Non-pyrogenic I.V. administration set with aseptic technique.
For I.V. use only.
Single Bolus + Short Infusion
Last up to 18hours

CAUTION & WARNING:

CAUTION: It is dangerous to take this preparation except in accordance with the medical advice.
Not to be sold by retail without the prescription of a Registered Medical Practitioner.
WARNING: Do not use the bottle if plastic bag is missing or tampered.

STORAGE & DOSAGE:

Storage: Store at 25°C with excursions permitted between 15°C -20°C.
Do not freeze.
Protect from light during storage.
STERILE, NON-PYROGENIC, SINGLE DOSE CONTAINER.
Keep medicine out of reach of children.
FOR HUMAN USE ONLY
Read enclosed leaflet before use.
Dosage: As directed by the Physician.

Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml) Technical Specification: 

Product Name:Tirofiban Hydrochloride I.V. Injection
Brand Name:Aggrixtaj
Strength:(5mg/100ml or 50mcg/ml), (12.5mg/250ml or 50mcg/ml)
Dosage Form:I.V. Infusion Bottle (LVP)
Packing:100mL, 250mL IV Bottle
Route of Administration:For I.V. use only
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Antiplatelet Agents – Cardiovascular (Glycoprotein IIb/IIIa Inhibitors).
Indication: Tirofiban is indicated for the prevention of early myocardial infarction in adult patients presenting with acute coronary syndromes without ST elevation (NSTE-ACS) with the last episode of chest pain occurring within 12 hours and with ECG changes and/or elevated cardiac enzymes.
Storage:Store at 25°C with excursions permitted between 15°C -20°C. Do not freeze. Protect from light during storage.

Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml) Manufacturers and Suppliers in India:

Taj Pharmaceuticals is one of the prominent Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml) Manufacturers in India that brings the best quality products. Our company Taj Pharma carries a rich experience in the niche manufacturing of Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml)

Taj Pharmaceuticals is a reputed manufacturer and Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml) Suppliers in India prefer Taj Pharma is best known for the topmost standards and consistent quality of its products.

Taj Pharma is a well-known Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml)  Manufacturer in India that gives the assurance of high- quality and high standards. Strict quality control ensures that every batch of medicine brings a harmonious standard.

Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml)  manufactured at Taj Pharma follows USP (United States Pharmacopeia); i.e. the product is manufactured to comply with USP quality standards which are considered the Best in the world. Further, Taj Pharma uses Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml)  grade best active ingredient to manufacture its Injections to comply with international standards of European products.

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Tirofiban Hydrochloride I.V. Injection (5mg/100ml or 50mcg/ml) (Aggrixtaj)
  • Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml or 50mcg/ml) (Aggrixtaj)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Tirofiban Hydrochloride I.V. Injection (5mg/100ml or 50mcg/ml)
    Composition:
    Each 100 ml contains:
    Tirofiban Hydrochloride
    Eq. to Tirofiban……………………………5mg
    Sodium Chloride BP……………………0.9%w/v
    Water for Injection USP…………………q.s.
  • Tirofiban Hydrochloride I.V. Injection (12.5mg/250ml or 50mcg/ml)
    Composition:
    Each 250 ml contains:
    Tirofiban Hydrochloride
    Eq. to Tirofiban……………………………12.5mg
    Sodium Chloride BP……………………2.25%w/v
    Water for Injection USP…………………q.s.

THERAPEUTIC INDICATIONS:

Tirofiban is indicated for the prevention of early myocardial infarction in adult patients presenting with acute coronary syndromes without ST elevation (NSTE-ACS) with the last episode of chest pain occurring within 12 hours and with ECG changes and/or elevated cardiac enzymes.
Also, prevent blood clots which can cause heart attacks or other health problems associated with excessive clotting.

DIRECTION OF USE:

To be used with Non-pyrogenic I.V. administration set with aseptic technique.
For I.V. use only.
Single Bolus + Short Infusion
Last up to 18 hours

CAUTION & WARNING:

CAUTION: It is dangerous to take this preparation except in accordance with the medical advice.
Not to be sold by retail without the prescription of a Registered Medical Practitioner.
WARNING: Do not use the bottle if a plastic bag is missing or tampered with.

STORAGE & DOSAGE:

Storage: Store at 25°C with excursions permitted between 15°C -20°C. Do not freeze. Protect from light during storage.
STERILE, NON-PYROGENIC, SINGLE DOSE CONTAINER.
Keep medicine out of reach of children.
FOR HUMAN USE ONLY
Read the enclosed leaflet before use.
Dosage: As directed by the Physician.

Why Taj Pharmaceuticals?

Taj Pharmaceuticals is a trusted and reputable choice for those seeking Tirofiban Hydrochloride I.V. Injection, and their credentials speak volumes. With a strong legacy and extensive experience in the pharmaceutical industry, Taj Pharmaceuticals demonstrates a profound understanding of critical medications like Tirofiban. Their track record of expertise is a testament to their commitment to excellence. One of Taj Pharmaceuticals’ standout attributes is its unwavering dedication to maintaining the highest standards of quality and safety in pharmaceutical products. This commitment is especially crucial when it comes to medications like Tirofiban, where precision and reliability are paramount.

Taj Pharmaceuticals extends its reach globally, not only as a manufacturer but also as an exporter from India. This global presence means that high-quality medications, such as Tirofiban, are accessible to healthcare providers and patients worldwide. This accessibility contributes significantly to enhancing patient care on an international scale. The advanced manufacturing facilities under Taj Pharmaceuticals’ purview, including the Taj Pharma plant in Vapi, Gujarat, operate with stringent quality control measures. This meticulous approach ensures the accurate and consistent production of critical medications, instilling confidence in both healthcare professionals and patients.

Taj Pharmaceuticals has earned the trust and respect of healthcare providers, institutions, and patients alike. Their reputation as a reliable supplier of pharmaceuticals underscores their dedication to quality and safety in medical treatments. Taj Pharmaceuticals is guided by a patient-centric philosophy, placing the well-being of individuals at the forefront of its mission. This is exemplified through their commitment to providing dependable medications like Tirofiban Hydrochloride I.V. Injection. Their genuine dedication to improving patient outcomes in critical medical situations sets them apart as a trusted partner in healthcare.

What is Tirofiban Hydrochloride I.V. Injection and its uses?

Tirofiban Hydrochloride I.V. Injection is a medication used for its antiplatelet properties, primarily in the management of cardiovascular conditions. Here’s an overview of Tirofiban Hydrochloride I.V. Injection and its uses:

Medication Type: Tirofiban belongs to a class of drugs known as glycoprotein IIb/IIIa inhibitors. It specifically targets the glycoprotein IIb/IIIa receptors on the surface of platelets.

Uses:

  • Acute Coronary Syndrome (ACS): Tirofiban is commonly used in the treatment of ACS, a spectrum of conditions that includes unstable angina and myocardial infarction (heart attack). It helps prevent the formation of blood clots in the coronary arteries, maintaining blood flow to the heart muscle.
  • Percutaneous Coronary Intervention (PCI): Tirofiban is often administered during PCI procedures, such as angioplasty and stent placement, to prevent platelet aggregation and clot formation in the coronary arteries. It ensures the success of revascularization.
  • Coronary Artery Thrombosis: In emergency situations where there is acute thrombosis (clot formation) in the coronary arteries, Tirofiban can be used to rapidly dissolve the clot and restore blood flow.

Administration: Tirofiban Hydrochloride I.V. Injection is administered intravenously (IV) in a healthcare setting, usually during hospitalization. The dosage and duration of treatment are determined by the healthcare provider based on the patient’s condition and the specific procedure or diagnosis.

Mechanism of Action: Tirofiban works by inhibiting the glycoprotein IIb/IIIa receptors on the surface of platelets. These receptors play a crucial role in platelet aggregation and clot formation. By blocking these receptors, Tirofiban prevents platelets from binding together and forming clots, ensuring that blood flow in the coronary arteries remains unobstructed.

Duration of Action: Tirofiban has a relatively short duration of action, which allows for the rapid reversibility of its effects. This property is advantageous in emergency situations, as platelet function typically returns to normal within hours after discontinuation.

How does Tirofiban Hydrochloride I.V. Injection work?

Tirofiban Hydrochloride I.V. Injection works by targeting a specific process in the blood that is crucial for the formation of blood clots. Here’s how it works:

  • Platelet Aggregation: The formation of blood clots typically involves a component called platelets, which are small cell fragments in the blood. When an injury or damage occurs in a blood vessel, platelets are activated and start to clump together at the site of injury. This process is known as platelet aggregation.
  • Role of Glycoprotein IIb/IIIa Receptors: One of the key players in platelet aggregation is a group of receptors on the surface of platelets called glycoprotein IIb/IIIa receptors. These receptors play a crucial role in the binding of platelets to each other and to the damaged blood vessel wall.
  • Tirofiban’s Mechanism of Action: Tirofiban is classified as a glycoprotein IIb/IIIa inhibitor. It specifically targets and blocks these glycoprotein IIb/IIIa receptors on the surface of platelets.
  • Preventing Platelet Aggregation: When Tirofiban is administered intravenously (IV), it circulates in the bloodstream and binds to the glycoprotein IIb/IIIa receptors on the platelets. By doing so, it effectively blocks the activation of these receptors.
  • Inhibition of Platelet Clumping: With the glycoprotein IIb/IIIa receptors blocked by Tirofiban, platelets are unable to bind together or to the damaged blood vessel wall. This inhibition of platelet clumping prevents the formation of blood clots.
  • Maintenance of Blood Flow: By preventing platelet aggregation and clot formation, Tirofiban helps maintain blood flow within the blood vessels, particularly in the coronary arteries of the heart. This is crucial in conditions like acute coronary syndrome and during percutaneous coronary intervention (PCI) procedures, where restoring or maintaining blood flow is essential.

Benefits of Tirofiban Hydrochloride I.V. Injection:

  • Prevention of Blood Clots: Tirofiban is highly effective at preventing the formation of blood clots, particularly in the coronary arteries. This property is critical in conditions like acute coronary syndrome (ACS), where rapid clot formation can lead to heart attacks.
  • Maintenance of Blood Flow: By inhibiting platelet aggregation and clot formation, Tirofiban helps maintain blood flow in coronary arteries. This is essential for reducing the risk of cardiac complications and preserving heart muscle function.
  • Support for Percutaneous Coronary Intervention (PCI): Tirofiban is commonly used during PCI procedures, such as angioplasty and stent placement, to prevent clot formation in response to the intervention. This ensures the success of revascularization and minimizes the risk of complications.
  • Rapid Reversibility: Tirofiban has a relatively short duration of action, allowing its effects on platelet function to be rapidly reversed. This feature is advantageous in case immediate discontinuation is necessary.

Common Side Effects of Tirofiban Hydrochloride I.V. Injection:

  • Bleeding: One of the primary side effects of Tirofiban is an increased risk of bleeding. This can manifest as nosebleeds, gum bleeding, bruising, or, in more severe cases, gastrointestinal or internal bleeding.
  • Thrombocytopenia: Tirofiban can occasionally lead to a decrease in platelet count (thrombocytopenia), which can increase the risk of bleeding.
  • Headache: Some individuals may experience headaches as a side effect of Tirofiban.
  • Nausea and Vomiting: Gastrointestinal symptoms such as nausea and vomiting can occur in some patients.
  • Hypotension (Low Blood Pressure): Tirofiban can cause a drop in blood pressure in some cases, which may require medical attention.
  • Allergic Reactions: Although rare, allergic reactions to Tirofiban can occur. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing.

Frequently Asked Questions About Tirofiban Hydrochloride I.V. Injection

Certainly, here are some frequently asked questions (FAQs) about Tirofiban Hydrochloride I.V. Injection:

  • What is Tirofiban Hydrochloride I.V. Injection used for?

Tirofiban is primarily used to prevent the formation of blood clots, particularly in the coronary arteries. It is commonly used in conditions like acute coronary syndrome (ACS) and during percutaneous coronary intervention (PCI) procedures.

  • How is Tirofiban Hydrochloride I.V. Injection administered?

Tirofiban is administered intravenously (IV) in a healthcare setting, typically during hospitalization. The dosage and duration of treatment are determined by the healthcare provider based on the patient’s condition and the specific procedure or diagnosis.

  • Is Tirofiban Hydrochloride I.V. Injection a blood thinner (anticoagulant)?

Tirofiban is not a traditional anticoagulant; rather, it is a glycoprotein IIb/IIIa inhibitor. It specifically targets platelet activity to prevent clot formation, making it distinct from anticoagulants like heparin or warfarin.

  • What are the potential side effects of Tirofiban?

Common side effects of Tirofiban may include bleeding, thrombocytopenia (low platelet count), headache, nausea, vomiting, and, in some cases, hypotension (low blood pressure). Allergic reactions are rare but possible.

  • Can Tirofiban Hydrochloride I.V. Injection be used during pregnancy or breastfeeding?

The use of Tirofiban during pregnancy and breastfeeding should be carefully considered by healthcare providers, weighing the potential benefits against the potential risks. It is typically reserved for situations where the benefits clearly outweigh the risks.

  • How long does the effect of Tirofiban last?

Tirofiban has a relatively short duration of action, with its effects on platelet function typically reversible within hours after discontinuation. This allows for rapid reversibility, which can be important in emergency situations.

  • Are there any specific monitoring requirements during Tirofiban treatment?

Patients receiving Tirofiban are typically closely monitored for signs of bleeding, changes in platelet count, and other potential side effects. Regular blood tests may be performed to assess platelet function.

  • Can I continue taking other medications while receiving Tirofiban?

It’s essential to inform your healthcare provider about all medications and supplements you are taking, as some drugs may interact with Tirofiban. Your healthcare provider will consider potential interactions and adjust your treatment accordingly.
Always consult with a qualified healthcare provider for personalized information and guidance regarding Tirofiban Hydrochloride I.V. Injection, as individual circumstances and medical guidelines may vary.

As Tirofiban Hydrochloride I.V. Injection 12.5mg/250ml Exporters; We can cater to export business queries from the following geographies. We are exporting our Tirofiban Hydrochloride I.V. Injection 12.5mg/250ml product in the Following Countries:

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan, and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Tirofiban Hydrochloride I.V. Injection 12.5mg/250ml Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Tirofiban Hydrochloride I.V. Injection 12.5mg/250ml, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274