GENERIC NAME OF THE MEDICINAL PRODUCT:

A. Piperacillin & Tazobactam Injection IP 4.5gm
B. Piperacillin & Tazobactam Injection IP 2.25gm
C. Piperacillin &Tazobactam Injection IP 1.125gm

QUALITATIVE AND QUANTITATIVE COMPOSITION:

1. Piperacillin & Tazobactam Injection IP 4.5gm
a. Each vial contains:
Piperacillin Sodium (Sterile) IP
equivalent to Anhydrous piperacillin………………….4gm
Tazobactam Sodium (Sterile) IP
equivalent to Anhydrous Tazobactam……………..0.5gm
b. Sterile Water for injection IP ………………………….20ml


2. Piperacillin & Tazobactam Injection IP 2.25gm
a. Each vial contains:
Piperacillin Sodium (Sterile) IP
equivalent to Anhydrous piperacillin………………….2gm
Tazobactam Sodium (Sterile) IP
equivalent to Anhydrous Tazobactam…………..0.25gm
b. Sterile Water for injection IP ………………………….10ml

3. Piperacillin & Tazobactam Injection IP 1.125gm
a. Each vial contains:
Piperacillin Sodium (Sterile) IP
equivalent to Anhydrous piperacillin………………….1gm
Tazobactam Sodium (Sterile) IP
equivalent to Anhydrous Tazobactam…..……..0.125gm
b. Sterile Water for injection IP ………………………….10ml

THERAPEUTIC INDICATIONS:

Piperacillin and tazobactam injection are used to treat pneumonia and skin, gynecological, and abdominal (stomach area) infections caused by bacteria. Piperacillin is in a class of medications called penicillin antibiotics. It works by killing bacteria that cause infection.

DIRECTION OF USE:

Dissolve the contents of vial in 20ml/10ml of Sterile Water for Injections I.P. Use reconstituted solution immediately.

CAUTION & SCHEDULE:

CAUTION: If any foreign particle is visible after dissolving the contents, do not use & ask for replacement.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.
SCHEDULE: SCHEDULE H PRESCRIPTION DRUG-CAUTION: Not to be sold by retail without the prescription of a Registered Medical Practitioner.

STORAGE & DOSAGE:

STORAGE: Store below 25°C. Protect from Light & Moisture.
Reconstituted solution should be use immediately after preparation.
Any unused reconstitution portion must be discarded.
KEEP OUT OF REACH AND SIGHT OF CHILDREN.
DOSAGE: As directed by Physician.

Piperacillin & Tazobactam Injection IP 4.5gm Technical Specification:

Product Name:Piperacillin & Tazobactam Injection IP 4.5gm
Brand Name:Pipranem
Strength:4.5gm, 2.25gm, 1.125gm
Dosage Form:Sterile Dry Powder Injection
Packing:1 Vial + WFI in Tray
Route of Administration:For I.V. use only
Pack Insert/Leaflet:PIL (Patient Information Leaflet)
Documents:COA, MOA, Product Permission, Stability Studies, GMP
Therapeutic use:Anti-Bacterial & Anti-biotics
Indication: Piperacillin and tazobactam injections are used to treat pneumonia, skin, and abdominal infections caused by bacteria. It works by killing bacteria that cause infection.
Storage:Store below 25°C. Protect from Light & Moisture.

GENERIC NAME OF MEDICINAL PRODUCT:

  • Piperacillin & Tazobactam Injection IP 4.5gm

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Piperacillin & Tazobactam Injection IP 4.5gm
    Each vial contains:
    Piperacillin Sodium (Sterile) IP
    equivalent to Anhydrous piperacillin………………….4gm
    Tazobactam Sodium (Sterile) IP
    equivalent to Anhydrous Tazobactam……………..0.5gm
    Sterile Water for injection IP ………………………….20ml

THERAPEUTIC INDICATION:

Piperacillin and tazobactam injection is used to treat pneumonia and skin, gynecological, and abdominal (stomach area) infections caused by bacteria. Piperacillin is in a class of medications called penicillin antibiotics. It works by killing bacteria that cause infection.

DIRECTION OF USE:

Dissolve the contents of the vial in 20ml of Sterile Water for Injections I.P.
Use reconstituted solution immediately.

CAUTION & SCHEDULE:

CAUTION: If any foreign particle is visible after dissolving the contents, do not use it & ask for a replacement.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.

SCHEDULE: SCHEDULE H PRESCRIPTION DRUG-CAUTION: Not to be sold by retail without the prescription of a Registered Medical Practitioner

STORAGE & DOSAGE:

STORAGE: Store below 25°C. Protect from Light & Moisture.

The reconstituted solution should be used immediately after preparation.
Any unused reconstitution portion must be discarded.
KEEP OUT OF REACH AND SIGHT OF CHILDREN.

DOSAGE: As directed by the Physician.

Why Taj Pharmaceuticals?

Taj Pharmaceuticals is a leading provider of Piperacillin & Tazobactam Injection, a vital antibiotic combination that plays a crucial role in treating a variety of bacterial infections. Our unwavering dedication to pharmaceutical excellence, quality, and patient well-being has earned us a reputation as a trusted partner in the fight against infectious diseases. With a legacy spanning decades in the pharmaceutical industry, Taj Pharmaceuticals is committed to ensuring that every vial of Piperacillin & Tazobactam Injection meets the highest global standards of quality and safety. We prioritize accessibility, ensuring that healthcare providers have access to this life-saving medication to combat a wide spectrum of bacterial pathogens. Our state-of-the-art manufacturing facilities adhere to rigorous quality control protocols, guaranteeing the efficacy and safety of every dose. Whether for hospital use, critical care settings, or outpatient treatment, healthcare professionals trust Taj Pharmaceuticals for reliable and effective antibiotics. Choose Taj Pharmaceuticals for Piperacillin & Tazobactam Injection and experience pharmaceutical excellence that places patient health and well-being at the forefront. We are your dependable partner in the battle against bacterial infections, offering the quality and reliability you deserve for improved patient outcomes. Trust Taj Pharmaceuticals for your antibiotic needs.

What is Piperacillin & Tazobactam Injection and its uses:

Piperacillin & Tazobactam Injection is a medication that combines two active ingredients: piperacillin and tazobactam. It is classified as an antibiotic and is used for the treatment of various bacterial infections. Let’s explore its uses:

  1. Bacterial Infections:

Broad-spectrum Antibiotic: Piperacillin and tazobactam work together to create a broad-spectrum antibiotic that is effective against a wide range of bacterial pathogens.

Respiratory Infections: It can be used to treat respiratory tract infections, including pneumonia, bronchitis, and lung abscesses.

Intraabdominal Infections: Piperacillin & Tazobactam is effective in treating intraabdominal infections, such as peritonitis and abscesses within the abdominal cavity.

Skin and Soft Tissue Infections: It is used for skin and soft tissue infections, including cellulitis, infected wounds, and skin abscesses.

Urinary Tract Infections: The medication can be prescribed for urinary tract infections (UTIs) like pyelonephritis and complicated UTIs.

Sepsis: In severe cases of bacterial infections, especially those leading to sepsis (systemic infection), Piperacillin & Tazobactam may be administered to combat the infection.

  1. Hospital Acquired Infections:

This antibiotic is often used to treat infections that occur in hospital settings, including infections acquired during surgery or in intensive care units.

  1. Febrile Neutropenia:

Patients with febrile neutropenia, a condition characterized by a fever and a low white blood cell count, may receive Piperacillin & Tazobactam as an empiric treatment.

  1. Gynecological Infections:

It can be used to treat gynecological infections, such as pelvic inflammatory disease (PID) and postsurgical infections.

  1. Bone and Joint Infections:

Infections affecting the bones and joints, such as osteomyelitis and septic arthritis, may be treated with this antibiotic.

  1. Gastrointestinal Infections:

Some gastrointestinal infections, particularly those involving the appendix or diverticula, can be managed with Piperacillin & Tazobactam.

  1. Meningitis (Limited Use):

In certain cases, this medication may be considered for the treatment of bacterial meningitis, although other antibiotics are often preferred for this condition.

It’s important to note that Piperacillin & Tazobactam is a prescription medication and should only be used under the guidance of a healthcare provider. The choice of antibiotic and dosage depends on the specific type of infection, its severity, and the susceptibility of the causative bacteria to the medication. Patients should follow their healthcare provider’s instructions and complete the full course of treatment, even if symptoms improve before the medication is finished, to ensure the infection is completely eradicated.

How Does Piperacillin & Tazobactam Injection Work?

Piperacillin & Tazobactam Injection works through a combination of two active ingredients: piperacillin and tazobactam. These two components work synergistically to combat bacterial infections, offering a broad-spectrum antibiotic effect. Here’s how they work:

  1. Piperacillin:

Piperacillin is a beta lactam antibiotic that belongs to the penicillin class of antibiotics. It works by inhibiting the synthesis of the bacterial cell wall, which is essential for the structural integrity of bacteria.

Bacterial cell walls are composed of a complex network of peptidoglycan, which provides stability and protection to the bacterial cell. Piperacillin interferes with the enzymes responsible for crosslinking the peptidoglycan chains. As a result, it weakens the cell wall and disrupts its formation.

This weakening of the cell wall leads to increased permeability and vulnerability of the bacterial cell. It makes the cell more susceptible to osmotic pressure changes, ultimately causing the cell to burst (lyse) and die.

  1. Tazobactam:

Tazobactam is a beta lactamase inhibitor. Beta lactamase enzymes are produced by some bacteria and are responsible for breaking down and deactivating beta lactam antibiotics like penicillins and cephalosporins.

Tazobactam works by binding irreversibly to betalactamase enzymes. This binding prevents the enzymes from degrading piperacillin and other beta lactam antibiotics.

By inhibiting beta lactamase enzymes, tazobactam helps protect piperacillin from enzymatic degradation, allowing piperacillin to exert its antibacterial effect effectively.

Combined Effect:

Piperacillin and tazobactam, when administered together as a combination therapy, offer a potent antibiotic effect that is effective against a wide range of bacteria, including those that produce beta lactamase enzymes.

The combination provides a broad spectrum of coverage against Gram-positive and Gram-negative bacteria, making it suitable for treating various types of bacterial infections.

Overall, Piperacillin & Tazobactam Injection is an essential antibiotic that helps combat bacterial infections by disrupting the integrity of bacterial cell walls and protecting the active antibiotic component from degradation by bacterial enzymes. It is prescribed by healthcare providers based on the type of infection and the susceptibility of the causative bacteria.

Benefits of Piperacillin & Tazobactam Injection:

  • Broad-Spectrum Antibiotic: Piperacillin & Tazobactam is a broad-spectrum antibiotic effective against a wide range of bacterial pathogens, making it a valuable choice for empiric treatment of various infections.
  • Combination Therapy: The combination of piperacillin and tazobactam enhances the effectiveness of the antibiotic by protecting piperacillin from degradation by bacterial beta-lactamase enzymes. This allows for more potent and sustained antibacterial activity.
  • Treatment of Serious Infections: It is used to treat serious bacterial infections, including those acquired in healthcare settings (hospital-acquired infections). This antibiotic can combat infections that may not respond to narrower-spectrum antibiotics.
  • Effective Against Resistant Bacteria: Piperacillin & Tazobactam can be effective against bacteria that have developed resistance to other antibiotics, including beta-lactamase-producing strains.
  • Intra-Abdominal Infections: It is particularly useful in treating intra-abdominal infections, such as peritonitis and abscesses, where a broad-spectrum antibiotic is often required.

Side Effects of Piperacillin & Tazobactam Injection:

  • Allergic Reactions: Like all antibiotics, Piperacillin & Tazobactam can potentially cause allergic reactions, which may range from mild rashes and itching to severe reactions like anaphylaxis. Allergic reactions should be reported immediately to a healthcare provider.
  • Gastrointestinal Disturbances: Common side effects may include nausea, vomiting, diarrhea, and abdominal pain.
  • Injection Site Reactions: Pain, redness, or swelling at the injection site can occur.
  • Kidney Function: In some cases, this antibiotic may affect kidney function. Kidney function should be monitored during treatment, and adjustments to the dosage may be necessary in patients with impaired renal function.
  • Neurological Effects: Rarely, Piperacillin & Tazobactam may cause neurological effects such as seizures, especially in patients with preexisting neurological conditions or impaired kidney function.
  • Blood Disorders: Changes in blood cell counts, such as decreased white blood cell count (neutropenia) and platelet count (thrombocytopenia), may occur.

Frequently Asked Questions About Piperacillin & Tazobactam Injection:

Certainly, here are some frequently asked questions (FAQs) about Piperacillin & Tazobactam Injection:

  1. What is Piperacillin & Tazobactam Injection used for?

Piperacillin & Tazobactam Injection is used to treat a wide range of bacterial infections, including respiratory, urinary tract, skin and soft tissue, intraabdominal, and hospital acquired infections.

  1. How does Piperacillin & Tazobactam work?

This medication is a combination of two components, piperacillin (an antibiotic) and tazobactam (a beta lactamase inhibitor). Piperacillin inhibits bacterial cell wall synthesis, while tazobactam protects piperacillin from degradation by bacterial enzymes, enhancing its antibacterial effect.

  1. Is Piperacillin & Tazobactam effective against antibiotic resistant bacteria?

Yes, Piperacillin & Tazobactam is effective against some antibiotic resistant bacteria, including those that produce beta lactamase enzymes. It is often used in hospital settings where antibiotic resistance can be a concern.

  1. Are there any specific precautions to take when using this medication?

Patients should inform their healthcare provider of any allergies to antibiotics, especially penicillins or cephalosporins. It’s essential to complete the full course of treatment as prescribed, even if symptoms improve before finishing the medication.

  1. Can I drink alcohol while taking Piperacillin & Tazobactam?

It’s generally advisable to avoid alcohol while on antibiotics. Alcohol can interfere with the effectiveness of antibiotics and may also worsen potential side effects.

  1. Can this medication be used during pregnancy or while breastfeeding?

Pregnant or breastfeeding individuals should discuss the risks and benefits of using Piperacillin & Tazobactam with their healthcare provider. The decision will depend on the specific clinical situation.

  1. What should I do if I miss a dose of Piperacillin & Tazobactam?

If you miss a dose, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double dose to make up for a missed one.

  1. Can Piperacillin & Tazobactam be used in children?

The use of this medication in pediatric patients is determined by a healthcare provider based on the child’s age, weight, and the specific infection being treated.

  1. What are the potential side effects of Piperacillin & Tazobactam Injection?

Common side effects may include gastrointestinal symptoms (nausea, vomiting, diarrhea), injection site reactions, and allergic reactions. Serious side effects, such as neurological effects or severe allergic reactions, are rare but should be reported promptly.

  1. Is this medication available in oral form, or is it only administered by injection?

Piperacillin & Tazobactam is typically administered by injection (intravenous or intramuscular) and is not available in oral form.

Patients should consult their healthcare provider or pharmacist for personalized information and guidance regarding the use of Piperacillin & Tazobactam Injection, including dosage, potential side effects, and any specific questions or concerns they may have.

As Piperacillin & Tazobactam Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Piperacillin & Tazobactam Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Piperacillin & Tazobactam Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Piperacillin & Tazobactam Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593