GENERIC NAME OF THE MEDICINAL PRODUCT:

A. Piperacillin and Tazobactam for Injection USP 4.5g
B. Piperacillin and Tazobactam for Injection USP 2.25g
C. Piperacillin and Tazobactam for Injection USP 1.125g

QUALITATIVE AND QUANTITATIVE COMPOSITION:

1. Piperacillin and Tazobactam for Injection USP 4.5g
a. Each vial contains:
Piperacillin Sodium (Sterile) USP
equivalent to piperacillin………………….4g
Tazobactam Sodium (Sterile)
equivalent to Tazobactam USP…………….500mg
b. Sterile Water for injection IP ………………………….20ml


2. Piperacillin and Tazobactam for Injection USP 2.25g
a. Each vial contains:
Piperacillin Sodium (Sterile) USP
equivalent to piperacillin………………….2g
Tazobactam Sodium (Sterile)
equivalent to Tazobactam USP…………….250mg
b. Sterile Water for injection IP ………………………….10ml

3. Piperacillin and Tazobactam for Injection USP 1.125g
a. Each vial contains:
Piperacillin Sodium (Sterile) USP
equivalent to piperacillin………………….1g
Tazobactam Sodium (Sterile)
equivalent to Tazobactam USP…………….125mg
b. Sterile Water for injection IP ………………………….10ml

THERAPEUTIC INDICATIONS:

Piperacillin and tazobactam injection is used to treat pneumonia and skin, gynecological, and abdominal (stomach area) infections caused by bacteria. Piperacillin is in a class of medications called penicillin antibiotics. It works by killing bacteria that cause infection.

DIRECTION OF USE:

Dissolve the contents of vial in 20ml/10ml of Sterile Water for Injections I.P.
Use reconstituted solution immediately.

CAUTION AND SCHEDULE:

CAUTION: If any foreign particle is visible after dissolving the contents, do not use & ask for replacement.
*Not to be sold without water for Injection.
SCHEDULE: SCHEDULE 'H PRESCRIPTION DRUG-WARNING:
-It is dangerous to take this preparation accept in accordance with the medical advice.
-Not to be sold by retail without the prescription of a Registered Medical Practitioner.
KEEP OUT OF REACH AND SIGHT OF CHILDREN.

STORAGE & DOSAGE:

STORAGE: Store below 25°C.
Protect from light.
Do not freeze.
DOSAGE: As directed by Physician.
Note: Water for Injection IP Ampoule is not manufactured by us.

Piperacillin and Tazobactam for Injection USP 4.5g Technical Specification:

Product Name:Piperacillin and Tazobactam for Injection USP 4.5g
Brand Name:Pipranem
Strength:4.5g, 2.25g, 1.125g
Dosage Form:Sterile Dry Powder Injection
Packing:1 Vial + WFI in Tray
Route of Administration:For I.V. use only
Pack Insert/Leaflet:PIL (Patient Information Leaflet)
Documents:COA, MOA, Product Permission, Stability Studies, GMP
Therapeutic use:Anti-Bacterial & Anti-biotics
Indication: Piperacillin and tazobactam injection are used to treat pneumonia, skin, and abdominal infections caused by bacteria. It works by killing bacteria that cause infection.
Storage:Store below 25°C. Protect from light. Do not freeze.

GENERIC NAME OF MEDICINAL PRODUCT:

  • Piperacillin and Tazobactam for Injection USP 4.5g

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Piperacillin and Tazobactam for Injection USP 4.5g
    Each vial contains:
    Piperacillin Sodium (Sterile) USP
    equivalent to piperacillin………………….4g
    Tazobactam Sodium (Sterile)
    equivalent to Tazobactam USP…………….500mg
    Sterile Water for injection IP ………………………….20ml

THERAPEUTIC INDICATION:

Piperacillin and tazobactam injection is used to treat pneumonia and skin, gynecological, and abdominal (stomach area) infections caused by bacteria. Piperacillin is in a class of medications called penicillin antibiotics. It works by killing bacteria that cause infection.

DIRECTION OF USE:

Dissolve the contents of vial in 20ml of Sterile Water for Injections I.P.
Use reconstituted solution immediately.

CAUTION AND SCHEDULE:

CAUTION: If any foreign particle is visible after dissolving the contents, do not use & ask for replacement.
Not to be sold without water for Injection.
SCHEDULE: SCHEDULE ‘H PRESCRIPTION DRUG-WARNING:
It is dangerous to take this preparation accept in accordance with the medical advice.
Not to be sold by retail without the prescription of a Registered Medical Practitioner.
KEEP OUT OF REACH AND SIGHT OF CHILDREN.

STORAGE AND DOSAGE:

STORAGE: Store below 25°C. Protect from light. Do not freeze.
DOSAGE: As directed by Physician.
Note: Water for Injection IP Ampoule is not manufactured by us.

Why Taj Pharmaceuticals?

Taj Pharmaceuticals is a renowned pharmaceutical company known for its commitment to providing high-quality medications to improve global healthcare. With a strong emphasis on quality assurance, Taj Pharmaceuticals ensures that every product, including Piperacillin and Tazobactam for Injection, meets the highest standards of safety and efficacy. Their manufacturing facilities adhere to stringent quality control measures, making them a trusted source for pharmaceuticals. The company boasts a wealth of expertise and experience, with a history spanning decades in the pharmaceutical industry. This extensive experience has been instrumental in their ability to develop and manufacture medications that are not only effective but also reliable and safe for patients worldwide. Taj Pharmaceuticals places a significant focus on research and development, enabling them to stay at the forefront of pharmaceutical innovation. This commitment to R&D ensures that their products incorporate the latest advancements in the field, making them a reliable choice for healthcare professionals and patients seeking cutting-edge treatments.

One of Taj Pharmaceuticals’ notable strengths is its global reach. They export their pharmaceutical products to numerous countries, demonstrating their dedication to making essential medications accessible to patients across the globe. This global presence is a testament to their commitment to improving global healthcare. Regulatory compliance is another cornerstone of Taj Pharmaceuticals’ operations. They adhere to strict regulatory standards, both nationally and internationally, ensuring that their products consistently meet safety and quality requirements. This commitment to compliance instills confidence in healthcare providers and patients alike. Taj Pharmaceuticals offers a comprehensive product portfolio that spans various medical conditions. This diversity empowers healthcare providers to choose the most suitable treatment options for their patients, further underscoring the company’s patient-centric approach. Environmental responsibility is also a key focus for Taj Pharmaceuticals. They are committed to sustainable and environmentally friendly practices in their manufacturing processes, demonstrating their dedication to minimizing their ecological footprint and contributing to a healthier planet. In summary, Taj Pharmaceuticals is a trusted and reputable pharmaceutical company with a rich history, a global presence, and a commitment to delivering high-quality medications like Piperacillin and Tazobactam for Injection. Their dedication to quality, research, and environmental sustainability makes them a valuable player in the pharmaceutical industry, benefiting both healthcare providers and patients worldwide.

What is Piperacillin and Tazobactam for Injection and its uses:

Piperacillin and Tazobactam for Injection is a combination medication used in the field of healthcare to treat various bacterial infections. This medication consists of two active ingredients, piperacillin and tazobactam, which work together to combat bacterial infections effectively.
Piperacillin: Piperacillin is a broad-spectrum antibiotic classified as a penicillin. It works by interfering with the formation of the bacterial cell wall, which is essential for the structural integrity of bacteria. By disrupting the cell wall, piperacillin weakens the bacteria, making it more susceptible to the body’s immune system and other antibiotics. Piperacillin is effective against a wide range of bacteria, including both gram-positive and gram-negative bacteria.
Tazobactam: Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are enzymes produced by some bacteria that can break down certain antibiotics, such as penicillins and cephalosporins, rendering them ineffective. Tazobactam inhibits these enzymes, protecting piperacillin from degradation by beta-lactamases. This combination of piperacillin and tazobactam enhances the spectrum and effectiveness of the antibiotic against a broader range of bacteria.

Uses:

Piperacillin and Tazobactam for Injection is prescribed by healthcare professionals to treat various types of infections, including but not limited to:

  • Intra-abdominal Infections: These are infections within the abdominal cavity and organs, often caused by bacteria from the gastrointestinal tract.
  • Lower Respiratory Tract Infections: Including pneumonia and lung abscesses caused by susceptible bacteria.
  • Skin and Soft Tissue Infections: Such as cellulitis, skin abscesses, and infected wounds.
  • Urinary Tract Infections: Including complicated urinary tract infections.
  • Gynecological Infections: Such as pelvic inflammatory disease.
  • Septicemia (Bloodstream Infections): When bacteria enter the bloodstream, leading to systemic infections.
  • Infections in Immunocompromised Patients: People with weakened immune systems may be more susceptible to bacterial infections, and Piperacillin and Tazobactam can be used in such cases.

It’s important to note that this medication should only be used under the guidance and prescription of a healthcare provider. The choice of antibiotic and its specific use will depend on the type of infection, the causative bacteria, and the patient’s medical condition.

How does Piperacillin and Tazobactam for Injection work?

Piperacillin and Tazobactam for Injection is a combination medication that works synergistically to combat bacterial infections. It consists of two active components: piperacillin and tazobactam, each with a specific role in targeting and eliminating bacteria.

Here’s how Piperacillin and Tazobactam work together to combat bacterial infections:

Piperacillin: Piperacillin is a broad-spectrum antibiotic belonging to the penicillin class. Its primary mode of action is to inhibit the synthesis of bacterial cell walls. Bacterial cells rely on their cell walls to maintain structural integrity and protect themselves from the external environment. Piperacillin interferes with the formation of the bacterial cell wall by inhibiting the enzymes involved in its synthesis. This leads to the weakening of the cell wall and, ultimately, the bursting of the bacterial cell due to increased osmotic pressure. As a result, the bacteria lose their structural integrity and are vulnerable to attack by the immune system and other antibiotics.
Tazobactam: Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are enzymes produced by some bacteria that have the ability to break down and inactivate certain antibiotics, particularly penicillins and cephalosporins. By inhibiting these beta-lactamase enzymes, tazobactam effectively protects piperacillin from degradation. This means that piperacillin can remain active in the presence of beta-lactamases, which are often produced by antibiotic-resistant bacteria. This combination allows piperacillin to target a broader range of bacteria and enhances its effectiveness.

In summary, Piperacillin and Tazobactam for Injection work together to disrupt the structure of bacterial cell walls, making the bacteria more susceptible to immune system attacks and other antibiotics. Additionally, tazobactam helps preserve the activity of piperacillin by inhibiting beta-lactamase enzymes, which are often used by bacteria to resist the effects of antibiotics. This combination of actions makes Piperacillin and Tazobactam a potent and versatile antibiotic for the treatment of a wide range of bacterial infections.

Benefits of Piperacillin and Tazobactam for Injection:

  • Effective Against a Broad Spectrum of Bacteria: Piperacillin and Tazobactam for Injection is a broad-spectrum antibiotic that can target a wide range of bacteria, including both Gram-positive and Gram-negative strains. This makes it suitable for treating various types of bacterial infections.
  • Synergistic Action: The combination of piperacillin and tazobactam in a single medication offers a synergistic effect. Tazobactam inhibits beta-lactamase enzymes, which can break down and inactivate piperacillin. This allows piperacillin to remain active and effective against beta-lactamase-producing bacteria.
  • Treatment of Severe Infections: Piperacillin and Tazobactam are often used to treat serious infections, such as intra-abdominal infections, respiratory tract infections, skin and soft tissue infections, and more. Its potency makes it suitable for tackling infections that may not respond well to other antibiotics.
  • Hospital-Acquired Infections: This medication is commonly used in hospital settings to combat infections that patients may acquire during their hospital stay, including those caused by antibiotic-resistant bacteria.

Side Effects of Piperacillin and Tazobactam for Injection:

  • Allergic Reactions: Like many antibiotics, Piperacillin and Tazobactam can trigger allergic reactions in some individuals. Symptoms may include skin rashes, itching, swelling, and, in rare cases, severe allergic reactions like anaphylaxis.
  • Gastrointestinal Distress: Common side effects include nausea, vomiting, diarrhea, and abdominal pain. These symptoms are usually mild and transient.
  • Liver and Kidney Function: Some patients may experience changes in liver or kidney function while taking this medication. Monitoring of liver and kidney function may be necessary during treatment.
  • Hematologic Effects: Rarely, Piperacillin and Tazobactam can affect blood cell counts, leading to conditions like leukopenia (low white blood cell count) or thrombocytopenia (low platelet count).
  • Neurological Effects: High doses or prolonged use of this antibiotic can lead to neurological side effects, including seizures. This is more common in individuals with a history of seizures.
  • Superinfections: Prolonged use of antibiotics can lead to the development of superinfections, where new infections occur as a result of the disruption of the normal balance of microorganisms in the body.

It’s important to note that the benefits of using Piperacillin and Tazobactam typically outweigh the risks, especially when treating severe bacterial infections. However, like all medications, it should be used under the guidance of a healthcare professional, and any unusual or severe side effects should be reported promptly. Patients with known allergies to penicillin or cephalosporin antibiotics should inform their healthcare provider, as they may have an increased risk of allergic reactions to Piperacillin and Tazobactam.

Frequently Asked Questions About Piperacillin and Tazobactam for Injection:

  1. What is Piperacillin and Tazobactam for Injection used for?

Piperacillin and Tazobactam for Injection is primarily used to treat a wide range of bacterial infections, including respiratory, urinary tract, intra-abdominal, skin and soft tissue, and gynecological infections. It’s often employed in hospital settings to address serious infections, including those caused by antibiotic-resistant bacteria.

  1. How is Piperacillin and Tazobactam administered?

This medication is administered intravenously (IV) by a healthcare professional. The dosage and duration of treatment will depend on the specific infection being treated and the patient’s medical condition.

  1. Are there any contraindications or precautions for using Piperacillin and Tazobactam?

Patients with a history of severe allergic reactions to penicillin or cephalosporin antibiotics should exercise caution when using Piperacillin and Tazobactam, as they may have an increased risk of allergic reactions. It’s important to inform your healthcare provider of any known allergies or medical conditions before starting treatment.

  1. What are the common side effects of Piperacillin and Tazobactam for Injection?

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, and skin rashes. These side effects are generally mild and transient. However, more serious side effects, such as allergic reactions, neurological effects, or changes in liver and kidney function, can occur, although they are less common.

  1. Can Piperacillin and Tazobactam be used during pregnancy or while breastfeeding?

Piperacillin and Tazobactam should only be used during pregnancy or breastfeeding if the potential benefits outweigh the risks, and under the supervision of a healthcare provider. The decision should be based on the specific clinical situation.

  1. Can this medication interact with other drugs?

Yes, Piperacillin and Tazobactam can interact with other medications. It’s essential to inform your healthcare provider about all the drugs you are taking, including prescription, over-the-counter, and herbal supplements, to avoid potential drug interactions.

  1. How should I store Piperacillin and Tazobactam for Injection?

This medication is typically stored by healthcare professionals in a controlled environment. Patients should not store or attempt to use it at home. Always follow the storage instructions provided by your healthcare provider or pharmacist for any medications given to you.

  1. Is Piperacillin and Tazobactam effective against all types of bacteria?

While Piperacillin and Tazobactam have a broad spectrum of activity and can target many bacterial strains, they may not be effective against certain antibiotic-resistant bacteria. Your healthcare provider will choose the most appropriate antibiotic based on the specific infection and bacterial susceptibility testing when necessary.

  1. What should I do if I miss a dose of Piperacillin and Tazobactam for Injection?

Since this medication is administered by a healthcare professional, it is unlikely that you will miss a dose. However, if you have any concerns or questions about your treatment, consult your healthcare provider promptly.

  1. Can I drink alcohol while receiving Piperacillin and Tazobactam treatment?

It’s generally advisable to avoid alcohol while taking antibiotics, as alcohol can interfere with the body’s ability to process medications and may exacerbate certain side effects. Always consult your healthcare provider for personalized advice on alcohol consumption during treatment.

As Piperacillin and Tazobactam for Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Piperacillin and Tazobactam for Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Piperacillin and Tazobactam for Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Piperacillin and Tazobactam for Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274