GENERIC NAME OF MEDICINAL PRODUCT:

A. Methylprednisolone Sodium Succinate for Injection USP 2gm
B. Methylprednisolone Sodium Succinate for Injection USP 1gm
C. Methylprednisolone Sodium Succinate for Injection USP 500mg
D. Methylprednisolone Sodium Succinate for Injection USP 125mg
E. Methylprednisolone Sodium Succinate for Injection USP 40mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

A. Methylprednisolone Sodium Succinate for Injection USP 2gm
a. Each vial contains:
Methylprednisolone Sodium Succinate USP
Eq. to Methylprednisolone………2g
b. This pack is also contains:
One FFS ampule of Sterile Water For Injection USP………20ml

B. Methylprednisolone Sodium Succinate for Injection USP 1gm
a. Each vial contains:
Methylprednisolone Sodium Succinate USP
Eq. to Methylprednisolone………1g
b. This pack is also contains:
One FFS ampule of Sterile Water For Injection USP…………20ml

C. Methylprednisolone Sodium Succinate for Injection USP 500mg
a. Each vial contains:
Methylprednisolone Sodium Succinate USP
Eq. to Methylprednisolone………0.5g
b. This pack is also contains:
One FFS ampule of Sterile Water For Injection USP……….10ml

D. Methylprednisolone Sodium Succinate for Injection USP 125mg
a. Each vial contains:
Methylprednisolone Sodium Succinate USP
Eq. to Methylprednisolone………125mg
b. This pack is also contains:
One FFS ampule of Sterile Water For Injection USP………5ml


E. Methylprednisolone Sodium Succinate for Injection USP 40mg
a. Each vial contains:
Methylprednisolone Sodium Succinate USP
Eq. to Methylprednisolone………40mg
b. This pack is also contains:
One FFS ampule of Sterile Water For Injection USP……..5ml

THERAPEUTIC INDICATION:

Methylprednisolone is a Corticosteroid that prevents the release of substances in the body that cause inflammation. Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.

DIRECTION OF USE:

Reconstitute using Sterile Water for injection USP.
Reconstituted solution should be use immediately after preparation.
Administer/assist with patient provided emergency Injection. If not available use one locally approved steroid IM/IV.
Read enclosed leaflet before reconstitution and use.

CAUTION & WARNING:

CAUTION: Do not use, if constituent solution content Particle/suspended material.
If any particle is visible after dissolving the content do not use & return for replacement.
The formulations containing benzyl alcohol should not be used in neonates.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE
WARNING: To be sold by the retail on the prescription of a registered medical practitioner only.
Keep out of reach of medicine children.

STORAGE & DOSAGE:

Storage: Store below 25°C. Protect from light. Do not freeze.
Dosage: As directed by Physician.

Methylprednisolone Sodium Succinate for Injection USP 125mg Technical Specification:

Product Name:Methylprednisolone Sodium Succinate for Injection USP 125mg
Brand Name:M-Prednitaj
Strength:2gm, 1gm,  500mg, 125mg, 40mg
Dosage Form:Lyophilized Powder for Injection (Sterile)
Packing:1 Vial + WFI
Route of Administration:For I.V. used only
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Corticosteroid, Anti-inflammatory, Anti-allergic
Indication: Methylprednisolone is a Corticosteroid that prevents the release of substances in the body that cause inflammation. Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.
Storage:Store below 25°C. Protect from light. Do not freeze.

GENERIC NAME OF MEDICINAL PRODUCT:

  • Methylprednisolone Sodium Succinate for Injection USP 125mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Methylprednisolone Sodium Succinate for Injection USP 125mg
    a. Each vial contains:
    Methylprednisolone Sodium Succinate USP
    Eq. to Methylprednisolone……125mg
    b. This pack is also contains:
    One FFS ampule of Sterile Water For Injection USP……5ml

THERAPEUTIC INDICATION:

Methylprednisolone is a Corticosteroid that prevents the release of substances in the body that cause inflammation. Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.

DIRECTION OF USE:

Reconstitute using Sterile Water for injection USP.
Reconstituted solution should be use immediately after preparation.
Administer/assist with patient provided emergency Injection. If not available use one locally approved steroid IM/IV.}
Read enclosed leaflet before reconstitution and use.

CAUTION & Warning:

CAUTION:  Do not use, if constituent solution content Particle/suspended material.
If any particle is visible after dissolving the content do not use & return for replacement.
The formulations containing benzyl alcohol should not be used in neonates.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE
Warning: To be sold by the retail on the prescription of a registered medical practitioner only.
Keep out of reach of medicine children.

STORAGE & DOSAGE:

Storage: Store below 25°C. Protect from light. Do not freeze.
Dosage: As directed by Physician.

Why Taj Pharmaceuticals?

Taj Pharmaceuticals is a leading provider of Methylprednisolone Sodium Succinate for Injection, a vital medication used in critical care and anti-inflammatory treatments. Our unwavering dedication to quality, safety, and innovation ensures that every vial of Methylprednisolone Sodium Succinate meets rigorous global standards. With decades of experience in the pharmaceutical industry, Taj Pharmaceuticals has earned a reputation for delivering life-saving medications to healthcare professionals and patients worldwide. We prioritize accessibility, making sure that those in need have access to high-quality pharmaceuticals, including Methylprednisolone Sodium Succinate. Our state-of-the-art manufacturing facilities adhere to the most stringent quality control protocols, guaranteeing the purity and potency of every dose. Whether in emergency situations or planned medical interventions, healthcare providers trust Taj Pharmaceuticals for reliable and effective medications. Choose Taj Pharmaceuticals for Methylprednisolone Sodium Succinate for Injection, and experience pharmaceutical excellence that prioritizes your health and well-being. We stand as a beacon of trust and dependability in the world of healthcare, providing the quality and reliability you deserve in critical care and anti-inflammatory treatments.

What is Methylprednisolone Sodium Succinate for Injection and its uses:

Methylprednisolone Sodium Succinate for Injection is a medication used in various medical situations to address inflammation, immune system disorders, and critical care needs. Here’s an overview of Methylprednisolone Sodium Succinate for Injection and its primary uses:

  • Composition:
    Methylprednisolone Sodium Succinate is a synthetic corticosteroid medication. It is a water-soluble form of methylprednisolone that can be administered intravenously (IV).
  • Primary Uses:
    Anti-Inflammatory:
    Methylprednisolone Sodium Succinate is a potent anti-inflammatory medication. It is used to reduce inflammation and control inflammatory conditions, such as severe allergies, asthma, rheumatoid arthritis, and autoimmune diseases like lupus.
    Immunosuppression:
    In certain medical conditions where the immune system is overactive and causing harm, such as organ transplantation or autoimmune diseases, this medication is used to suppress immune responses and prevent rejection of transplanted organs or reduce autoimmune reactions.
    Acute and Critical Care:
    Methylprednisolone Sodium Succinate is often used in critical care situations, such as managing severe allergic reactions (anaphylaxis), treating severe respiratory conditions like acute asthma exacerbations, or addressing life-threatening inflammation, such as in cases of spinal cord injury or certain neurological disorders.
    Allergic Reactions:
    It can be administered to individuals experiencing severe allergic reactions when other treatments are ineffective or when a rapid response is required.
    Respiratory Distress Syndrome (RDS):
    In premature infants with respiratory distress syndrome, Methylprednisolone Sodium Succinate may be used to improve lung function and reduce inflammation in the airways.
  • Dosage and Administration:
    The dosage and administration of Methylprednisolone Sodium Succinate for Injection depend on the specific medical condition being treated, the severity of the condition, and the patient’s response to treatment. It is typically administered as an intravenous infusion under the supervision of healthcare professionals.
  • Duration of Treatment:
    The duration of treatment varies widely, ranging from short-term use in acute situations to more extended use in the management of chronic conditions. Treatment plans are determined by healthcare providers based on the patient’s needs.
    It’s important to note that Methylprednisolone Sodium Succinate is a potent medication with potential side effects. Its use should be closely monitored by healthcare providers, and the decision to use it should be carefully considered based on the patient’s medical condition and the expected benefits of treatment. In critical care situations, it can be a lifesaving medication, while in chronic conditions, it may be used to manage symptoms and improve quality of life.

How does Methylprednisolone Sodium Succinate for Injection work?

Methylprednisolone Sodium Succinate for Injection is a synthetic corticosteroid medication that exerts its therapeutic effects through several mechanisms in the body. Here’s how it works:

  • Anti-Inflammatory Effects:
    Methylprednisolone is a potent anti-inflammatory medication. It works by suppressing the inflammatory response in the body. Inflammation is a natural response to injury or infection, but in certain conditions, such as autoimmune diseases, allergies, and severe inflammation, the immune system can become overactive, causing tissue damage and other harmful effects.
    Methylprednisolone inhibits the release of inflammatory mediators like prostaglandins and leukotrienes. It also reduces the migration of immune cells to sites of inflammation, thereby dampening the inflammatory process.
  • Immunosuppressive Effects:
    Methylprednisolone has immunosuppressive properties, meaning it suppresses the activity of the immune system. This is particularly useful in conditions where the immune system is attacking the body’s own tissues, as seen in autoimmune diseases like rheumatoid arthritis and lupus.
    By suppressing immune responses, Methylprednisolone can help reduce inflammation and prevent further damage to tissues.
  • Allergic Reaction Suppression:
    In cases of severe allergic reactions, such as anaphylaxis, Methylprednisolone can suppress the exaggerated immune response that occurs during an allergic episode. It helps alleviate symptoms like swelling, rash, and respiratory distress.
  • Immune Cell Function Inhibition:
    Methylprednisolone affects the function of various immune cells, including lymphocytes and macrophages. It inhibits the activation and proliferation of these cells, reducing their ability to cause inflammation and tissue damage.
  • Stabilization of Cell Membranes:
    Methylprednisolone also has membrane-stabilizing properties. It can stabilize the membranes of cells, including those in the airways, which can help reduce swelling and inflammation in conditions like asthma.
  • Suppression of the Hypothalamic-Pituitary-Adrenal (HPA) Axis:
    Prolonged use of corticosteroids like Methylprednisolone can suppress the body’s natural production of cortisol, a hormone involved in the body’s stress response. This suppression of the HPA axis can lead to adrenal insufficiency, which is why corticosteroids are typically tapered off slowly when discontinuing treatment.

It’s important to note that while Methylprednisolone Sodium Succinate for Injection is highly effective at reducing inflammation and immune responses, it also carries potential side effects, especially with longterm or highdose use. The decision to use this medication is made by healthcare providers, taking into account the potential benefits and risks for each patient’s specific medical condition.

Benefits of Methylprednisolone Sodium Succinate for Injection:

  • Anti-Inflammatory Action: Methylprednisolone Sodium Succinate is highly effective at reducing inflammation, making it valuable in treating a wide range of inflammatory conditions, such as rheumatoid arthritis, lupus, and severe allergic reactions.
  • Immunosuppression: The medication suppresses the immune system’s activity, which is beneficial in autoimmune diseases where the immune system mistakenly attacks the body’s own tissues. It helps prevent further tissue damage and alleviate symptoms.
  • Swift Action: When administered intravenously, Methylprednisolone Sodium Succinate can act quickly, making it suitable for acute situations like severe allergic reactions or critical care scenarios where a rapid response is essential.
  • Respiratory Support: It can be used to manage severe respiratory conditions, including acute asthma exacerbations, to reduce airway inflammation and improve breathing.
  • Pain Relief: In some conditions, such as certain joint diseases, Methylprednisolone can provide significant pain relief by reducing inflammation in affected joints.
  • Critical Care Use: It is a crucial medication in critical care settings, including the treatment of spinal cord injury and certain neurological conditions, where reducing inflammation and minimizing tissue damage are essential.

Side Effects of Methylprednisolone Sodium Succinate for Injection:

  • Immunosuppression: While immunosuppression is a therapeutic benefit in certain situations, it can increase the risk of infections, including opportunistic infections. Patients should be monitored for signs of infection during treatment.
  • Metabolic Effects: Prolonged use or high doses of corticosteroids like Methylprednisolone can lead to metabolic changes, such as weight gain, increased blood sugar levels (hyperglycemia), and potential worsening of diabetes in susceptible individuals.
  • Adrenal Suppression: Long-term use can suppress the body’s natural production of cortisol, potentially leading to adrenal insufficiency. Discontinuing the medication must be done carefully to allow the adrenal glands to recover their function.
  • Bone Health: Corticosteroids can weaken bones, increasing the risk of osteoporosis and fractures, especially with long-term use.
  • Gastrointestinal Issues: Side effects may include stomach irritation, ulcers, and even gastrointestinal bleeding, particularly when corticosteroids are taken orally.
  • Mood and Behavior Changes: Some individuals may experience mood swings, anxiety, or even mood disorders while on corticosteroid treatment.
  • Fluid Retention: Methylprednisolone can cause fluid retention, leading to swelling and increased blood pressure in some cases.
  • Cataracts and Glaucoma: Long-term use may increase the risk of cataracts and glaucoma, which affect eye health.
  • Skin Changes: Corticosteroids can lead to thinning of the skin, making it more susceptible to bruising and skin damage.

It’s important to note that the benefits of Methylprednisolone Sodium Succinate should be carefully weighed against the potential side effects. The medication is typically prescribed for short-term use in acute situations or for managing chronic conditions with the lowest effective dose to minimize side effects. Patients should be monitored closely by healthcare providers during treatment, and the medication should be tapered off gradually when discontinuing to prevent withdrawal symptoms.

Frequently Asked Questions About Methylprednisolone Sodium Succinate for Injection:

Certainly, here are some frequently asked questions (FAQs) about Methylprednisolone Sodium Succinate for Injection:

  1. What is Methylprednisolone Sodium Succinate for Injection used for?

Methylprednisolone Sodium Succinate is used to treat a wide range of medical conditions characterized by inflammation, immune system disorders, and acute or critical care needs. It is prescribed for conditions such as rheumatoid arthritis, lupus, severe allergic reactions, and respiratory distress.

  1. How does Methylprednisolone Sodium Succinate work?

Methylprednisolone Sodium Succinate works by reducing inflammation and suppressing the immune system’s activity. It inhibits the release of inflammatory mediators and dampens immune responses, helping alleviate symptoms and prevent further tissue damage.

  1. Is Methylprednisolone Sodium Succinate the same as oral prednisone or prednisolone?

While Methylprednisolone Sodium Succinate belongs to the same class of medications as prednisone and prednisolone (corticosteroids), it is administered intravenously and is often used in acute or critical care situations, providing rapid relief.

  1. Can it be used for pain relief?

Methylprednisolone can provide pain relief in certain conditions, particularly when pain is caused by inflammation, such as joint inflammation in rheumatoid arthritis.

  1. What are the potential side effects of Methylprednisolone Sodium Succinate?

Side effects may include immunosuppression, metabolic changes, adrenal suppression, bone health issues, gastrointestinal problems, mood changes, fluid retention, eyerelated problems, and skin changes. The risk of side effects depends on the dosage, duration of treatment, and individual factors.

  1. Is Methylprednisolone Sodium Succinate safe during pregnancy and breastfeeding?

The use of Methylprednisolone during pregnancy or breastfeeding should be discussed with healthcare providers, as it depends on the specific medical condition and potential risks and benefits.

  1. How is the medication administered?

Methylprednisolone Sodium Succinate is administered intravenously by healthcare professionals. The dosage and duration of treatment vary depending on the patient’s condition.

  1. Can the medication be abruptly stopped?

Abruptly stopping Methylprednisolone Sodium Succinate after prolonged use can lead to withdrawal symptoms and adrenal insufficiency. It should be tapered off gradually under medical supervision.

  1. Can it interact with other medications?

Yes, Methylprednisolone can interact with other medications. Patients should inform their healthcare providers about all medications and supplements they are taking to prevent potential interactions.

  1. Is it safe to receive Methylprednisolone Sodium Succinate for Injection in a critical care setting?

Yes, it is considered safe when administered by trained healthcare professionals in a critical care setting. The benefits of rapid symptom relief and inflammation reduction often outweigh the potential risks.

Patients should discuss any concerns or questions about Methylprednisolone Sodium Succinate with their healthcare providers to ensure safe and effective treatment tailored to their specific medical needs.

As Methylprednisolone Sodium Succinate for Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Methylprednisolone Sodium Succinate for Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Methylprednisolone Sodium Succinate for Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Methylprednisolone Sodium Succinate for Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593