GENERIC NAME OF MEDICINAL PRODUCT:

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 2%w/v +(1:80,000)
Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 2%w/v +(1:200,000)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 2%w/v +(1:80,000)
Each ml contains:
Lignocaine Hydrochloride ……………..21.33mg
Equivalent to anhydrous
Lignocaine Hydrochloride…………………20mg
Adrenaline Bitartrate ……………………0.0225mg
(Equivalent to Adrenaline…………………0.0125mg)
Sodium Chloride …………………………..6.0mg
Sodium Metabisulphite BP…………………0.5mg
Methylparaben (as preservative).…..1.0mg
Water for Injections ……………………….q.s


Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 2% w/v +(1:200,000)
Each ml contains:
Lignocaine Hydrochloride ……………..21.33mg
Equivalent to anhydrous
Lignocaine Hydrochloride…………………20mg
Adrenaline Bitartrate ……………………0.009mg
(Equivalent to Adrenaline…………………0.005mg)
Sodium Chloride …………………………..6.5mg
Potassium Metabisulfite BP…………………1.2mg
Methylparaben (as preservative)…..1.0mg
Water for Injections ……………………….q.s

THERAPEUTIC INDICATION:

ADRENALINE+LIGNOCAINE is used to reduce pain and discomfort caused by invasive medical procedures such as surgery, needle punctures or insertion of a breathing tube or catheter. It is also used to reduce the discomfort of contractions during labour.

DIRECTION OF USE:

For Intramuscular use only.

CAUTION AND SCHEDULE:

CAUTION: Do not use in case any foreign particulate matter is observed inside the vial.
Not to be given Intravenously.
Not more than 10 withdrawals.
To be administered after a test dose with adequate precaution to cope with any adverse reactions.
KEEP OUT OF REACH AND SIGHT OF CHILDREN.
SCHEDULE: SCHEDULE 'H PRESCRIPTION DRUG-CAUTION Not to be sold by retail without the prescription of a Registered Medical Practitioner.

STORAGE AND DOSAGE:

STORAGE: Store below 25℃.
Store in a cool, dry and dark place.
Protect from light.
DOSAGE: As directed by the Physician.
Refer enclosed leaflet.

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection Technical Specification:

Product Name:Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 
Brand Name:Generic
Strength:2% w/v + (1:200,000), 2%w/v +(1:80,000)
Dosage Form:Liquid Injection
Packing:30ml Multiple Dose Vial
Route of Administration:For I.M. use only
Pack Insert/Leaflet:PIL (Patient Information Leaflet), PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Documents:COA, MOA, Product Permission, Stability Studies, GMP
Therapeutic use:Local Anesthetic
Indication: Lignocaine & Adrenaline is used to reduce pain and discomfort caused by invasive medical procedures such as surgery, needle punctures or insertion of a breathing tube or catheter. It is also used to reduce the discomfort of contractions during labour.
Storage:Store in a cool, dark place.

GENERIC NAME OF MEDICINAL PRODUCT:

  1. Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 2%w/v +(1:80,000)
  2. Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 2%w/v +(1:200,000)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  1. Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 2%w/v +(1:80,000)
    Each ml contains:

    Lignocaine Hydrochloride ……………..21.33mg
    Equivalent to anhydrous
    Lignocaine Hydrochloride…………………20mg
    Adrenaline Bitartrate ……………………0.0225mg
    (Equivalent to Adrenaline…………………0.0125mg)
    Sodium Chloride …………………………..6.0mg
    Sodium Metabisulphite BP…………………0.5mg
    Methylparaben (as preservative).…..1.0mg
    Water for Injections ……………………….q.s
  2. Lignocaine Hydrochloride & Adrenaline Bitartrate Injection 2% w/v +(1:200,000)
    Each ml contains:
    Lignocaine Hydrochloride ……………..21.33mg
    Equivalent to anhydrous
    Lignocaine Hydrochloride…………………20mg
    Adrenaline Bitartrate ……………………0.009mg
    (Equivalent to Adrenaline…………………0.005mg)
    Sodium Chloride …………………………..6.5mg
    Potassium Metabisulfite BP…………………1.2mg
    Methylparaben (as preservative)…..1.0mg
    Water for Injections ……………………….q.s

THERAPEUTIC INDICATION:

ADRENALINE+LIGNOCAINE is used to reduce pain and discomfort caused by invasive medical procedures such as surgery, needle punctures or insertion of a breathing tube or catheter. It is also used to reduce the discomfort of contractions during labour.

DIRECTION OF USE:

For Intramuscular use only.

CAUTION AND SCHEDULE:

CAUTION: Do not use in case any foreign particulate matter is observed inside the vial. Not to be given Intravenously. Not more than 10 withdrawals.
To be administered after a test dose with adequate precaution to cope with any adverse reactions.
KEEP OUT OF REACH AND SIGHT OF CHILDREN.
SCHEDULE: SCHEDULE ‘H PRESCRIPTION DRUG-CAUTION Not to be sold by retail without the prescription of a Registered Medical Practitioner.

STORAGE AND DOSAGE:

STORAGE: Store below 25℃. Store in a cool, dry and dark place. Protect from light.
DOSAGE: As directed by the Physician. Refer enclosed leaflet.

Why Taj Pharmaceuticals?

Certainly, let’s elaborate on the reasons why healthcare professionals and institutions might consider Taj Pharmaceuticals for Lignocaine Hydrochloride & Adrenaline Bitartrate Injection:

  • Commitment to Quality and Manufacturing Standards: Taj Pharmaceuticals’ strong commitment to maintaining high-quality standards in the production of medications makes it an attractive choice. Healthcare professionals value suppliers that rigorously adhere to quality control measures and good manufacturing practices, ensuring the safety and efficacy of the medications they provide. The trust in product quality is paramount when selecting a pharmaceutical supplier.
  • Regulatory Approvals and Compliance: Taj Pharmaceuticals’ ability to obtain regulatory approvals from health authorities, such as the FDA or EMA, is a crucial factor. Having the necessary approvals assures healthcare providers that the medication meets stringent safety and efficacy standards. Compliance with regulatory requirements reflects a company’s dedication to meeting global pharmaceutical standards.
  • Product Availability and Reliability: The consistent availability of specific formulations and dosages of Lignocaine Hydrochloride & Adrenaline Bitartrate Injection is vital for healthcare institutions. Taj Pharmaceuticals’ reliability in maintaining an uninterrupted supply chain for critical medications can significantly influence their selection as a supplier. Dependability in delivering essential medicines ensures uninterrupted patient care.
  • Cost-Effectiveness and Pricing: Pricing and cost-effectiveness play a significant role in healthcare decision-making. Hospitals and healthcare providers must consider the affordability of medications while maintaining high standards of quality. Taj Pharmaceuticals’ competitive pricing and cost-effective solutions may make them an appealing choice for healthcare institutions looking to optimize their budgets without compromising patient care.
  • Customer Support and Service: Excellent customer support, timely delivery, and responsive communication are highly valued in the healthcare industry. Pharmaceutical companies that prioritize effective communication and provide responsive customer service can establish strong partnerships with healthcare providers. A reliable and supportive supplier enhances the overall healthcare experience.
  • Track Record and Reputation: A pharmaceutical company’s track record and reputation in the industry can influence healthcare professionals’ trust. Taj Pharmaceuticals’ history of ethical business practices, reliability, and consistency in delivering medications can contribute to a positive reputation, further solidifying its position as a trusted pharmaceutical supplier.
  • Research and Development: Investment in research and development (R&D) to improve existing medications or develop new formulations demonstrates a commitment to advancing patient care. Pharmaceutical companies that actively engage in R&D may offer healthcare providers enhanced treatment options and innovative solutions to address evolving medical needs.
  • Safety and Adverse Event Reporting: The presence of robust systems for reporting and managing adverse events associated with medications is crucial. Companies like Taj Pharmaceuticals that prioritize patient safety by ensuring effective adverse event monitoring and reporting mechanisms contribute to a safer healthcare environment.

In conclusion, the selection of a pharmaceutical supplier, such as Taj Pharmaceuticals, is a critical decision in healthcare settings. It involves considering factors like quality, regulatory compliance, reliability, affordability, customer support, reputation, research and development, and patient safety. A supplier that excels in these areas can significantly impact patient care and the overall success of healthcare institutions.

What is Lignocaine Hydrochloride & Adrenaline Bitartrate Injection and its uses?

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection is a medication that combines two active ingredients: lignocaine hydrochloride and adrenaline bitartrate. This combination is used for various medical purposes, and it has several potential uses:

  • Local Anesthesia: Lignocaine hydrochloride, also known as lidocaine hydrochloride, is a local anesthetic. When injected, it temporarily blocks nerve signals in a specific area, leading to loss of sensation and pain relief. The addition of adrenaline (epinephrine) to the injection serves two purposes: it constricts blood vessels at the injection site, which helps reduce bleeding and prolong the duration of the anesthetic effect.
  • Dental Procedures: Lignocaine Hydrochloride & Adrenaline Bitartrate Injection is commonly used in dentistry for procedures such as tooth extraction, dental fillings, and root canals. It helps numb the oral tissues, allowing for painless dental work.
  • Minor Surgical Procedures: This medication may also be used for minor surgical procedures, such as suturing wounds or removing small skin lesions. It provides local anesthesia to the area being treated, allowing the procedure to be performed without causing pain to the patient.
  • Cardiac Arrhythmia Treatment: In some cases, lignocaine hydrochloride may be used to treat certain types of cardiac arrhythmias (abnormal heart rhythms). It can help stabilize the heart’s electrical activity.
  • Emergency Medicine: Adrenaline (epinephrine) component of the injection can be used to treat severe allergic reactions (anaphylaxis) or cardiac arrest. Adrenaline acts as a potent vasoconstrictor, which can help improve blood pressure and increase blood flow to vital organs in emergency situations.
  • Ophthalmic Procedures: Lignocaine Hydrochloride & Adrenaline Bitartrate Injection may be used in ophthalmology for procedures such as eye surgeries or the removal of foreign bodies from the eye. It helps numb the eye and reduce bleeding during surgery.
  • Obstetrics and Gynecology: This injection may be used during childbirth for local anesthesia during episiotomies (surgical incisions to widen the vaginal opening) or other procedures.

It’s important to note that the use of Lignocaine Hydrochloride & Adrenaline Bitartrate Injection should be administered by qualified healthcare professionals, such as doctors, dentists, or nurses, who are trained in its proper use and dosage. The choice to use this medication and the specific dosage will depend on the patient’s medical condition and the procedure being performed.

As with any medication, there can be potential side effects and contraindications, so it’s essential to follow the guidance of a healthcare provider when using this medication.

How Does Lignocaine Hydrochloride & Adrenaline Bitartrate Injection Work?

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection combines two active ingredients, lignocaine hydrochloride (also known as lidocaine hydrochloride) and adrenaline bitartrate, to provide local anesthesia and vasoconstriction. Here’s how these components work together:

  • Lignocaine Hydrochloride (Lidocaine Hydrochloride):

Local Anesthetic Action: Lignocaine hydrochloride is a local anesthetic. It works by blocking nerve signals in the area where it is injected. Specifically, it inhibits the influx of sodium ions through voltagegated sodium channels in nerve cell membranes. By blocking sodium channels, lignocaine prevents the generation and conduction of nerve impulses. This results in a temporary loss of sensation in the injected area, providing pain relief.
Duration of Anesthetic Effect: Lignocaine on its own has a relatively short duration of action. However, when combined with adrenaline, the vasoconstrictive effects of adrenaline help slow the systemic absorption of lignocaine. This prolongs the duration of the anesthetic effect, allowing for longerlasting pain relief.

  • Adrenaline Bitartrate (Epinephrine):

Vasoconstrictive Action: Adrenaline (epinephrine) is a potent vasoconstrictor, meaning it causes blood vessels to constrict or narrow. When added to Lignocaine Hydrochloride Injection, adrenaline serves two important purposes:
Reducing Bleeding: The vasoconstrictive effect of adrenaline helps reduce bleeding at the site of injection. This is particularly valuable in surgical procedures, dental work, and other medical interventions where minimizing bleeding is essential for a clear surgical field or to control bleeding from minor blood vessels.
Prolonging Anesthetic Effect: Adrenaline also slows the absorption of lignocaine into the bloodstream. This action helps extend the duration of the local anesthetic effect. By delaying the systemic absorption of lignocaine, adrenaline allows for a more sustained pain relief, making it especially useful in procedures that require prolonged anesthesia.

In summary, Lignocaine Hydrochloride & Adrenaline Bitartrate Injection works by combining a local anesthetic (lignocaine) to provide pain relief with a vasoconstrictor (adrenaline) to reduce bleeding and extend the duration of the anesthetic effect. This combination is commonly used in various medical and dental procedures to ensure effective and longlasting local anesthesia while maintaining a bloodless surgical field. It should be administered by trained healthcare professionals in accordance with the specific medical or dental procedure being performed.

Benefits And Side Effects of Lignocaine Hydrochloride & Adrenaline Bitartrate Injection:

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection, which combines the local anesthetic lignocaine hydrochloride (lidocaine hydrochloride) and the vasoconstrictor adrenaline bitartrate (epinephrine), has several benefits and potential side effects:

Benefits:

  • Effective Local Anesthesia: Lignocaine Hydrochloride & Adrenaline Bitartrate Injection provides effective local anesthesia. It is commonly used in dental, surgical, and medical procedures to numb specific areas, allowing for painless procedures.
  • Reduced Bleeding: The addition of adrenaline (epinephrine) to the injection serves to constrict blood vessels at the site of injection. This vasoconstrictive effect helps reduce bleeding during procedures, leading to a clearer surgical field and better control of minor blood vessels.
  • Prolonged Anesthetic Effect: Adrenaline in the injection slows the systemic absorption of lignocaine. This prolongs the duration of the local anesthetic effect, allowing for longerlasting pain relief. It is especially valuable in procedures that require extended anesthesia.
  • Versatility: Lignocaine Hydrochloride & Adrenaline Bitartrate Injection has a wide range of applications, including dental procedures, minor surgeries, ophthalmic procedures, and more. Its versatility makes it a valuable tool for healthcare professionals.
  • Emergency Use: Adrenaline (epinephrine) in the injection can be used in emergency situations, such as treating severe allergic reactions (anaphylaxis) or cardiac arrest. Adrenaline acts as a potent vasoconstrictor, helping to improve blood pressure and blood flow to vital organs in critical situations.

Side Effects:

  • Local Anesthetic Side Effects: The local anesthetic component (lignocaine) can cause side effects such as:
    Numbness: Temporary numbness or loss of sensation at the injection site.
    Tingling or Itching: Some individuals may experience tingling or itching at the injection site.
    Swelling or Redness: Mild swelling or redness at the injection site can occur.
  • Cardiovascular Side Effects: The adrenaline (epinephrine) component of the injection can lead to cardiovascular side effects, especially when used in higher doses or in sensitive individuals. These side effects may include:
    Increased Heart Rate: Adrenaline can cause an increase in heart rate (tachycardia).
    Elevated Blood Pressure: Adrenaline may lead to elevated blood pressure (hypertension).
    Palpitations: Some individuals may experience palpitations or a sensation of a racing heart.
  • Central Nervous System Side Effects: In rare cases, systemic absorption of the medication can lead to central nervous system side effects, such as dizziness or nervousness.
  • Allergic Reactions: While uncommon, some individuals may experience allergic reactions to either lignocaine or adrenaline. Allergic reactions can range from mild skin rash to severe anaphylaxis.

It’s essential to remember that the likelihood and severity of side effects can vary from person to person and depend on factors such as the dose, route of administration, and individual sensitivity. Healthcare professionals are trained to administer this injection safely and monitor for adverse effects. Patients should inform their healthcare providers of any allergies or medical conditions before receiving Lignocaine Hydrochloride & Adrenaline Bitartrate Injection, and they should report any unusual or severe side effects promptly.

Frequently Asked Questions About Lignocaine Hydrochloride & Adrenaline Bitartrate Injection:

Certainly, here are some frequently asked questions (FAQs) about Lignocaine Hydrochloride & Adrenaline Bitartrate Injection:

  1. What is Lignocaine Hydrochloride & Adrenaline Bitartrate Injection used for?

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection is used for local anesthesia in various medical, dental, and surgical procedures. It provides pain relief and helps control bleeding at the site of injection.

  1. How does Lignocaine Hydrochloride & Adrenaline Bitartrate Injection work?

This injection combines lignocaine (a local anesthetic) to provide pain relief with adrenaline (epinephrine) to constrict blood vessels and reduce bleeding. Lignocaine blocks nerve signals in the injected area, while adrenaline prolongs the duration of the anesthetic effect and minimizes bleeding.

  1. What types of procedures commonly use this injection?

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection is used in a wide range of medical and dental procedures, including dental work, minor surgeries, ophthalmic procedures, and emergency situations like treating severe allergic reactions.

  1. Are there any contraindications or situations where this injection should not be used?

Yes, there are contraindications and precautions. For example, it should be used with caution in patients with certain heart conditions, known allergies to its components, or during pregnancy. It is important to discuss your medical history and any potential contraindications with your healthcare provider.

  1. How long does the anesthetic effect last with Lignocaine Hydrochloride & Adrenaline Bitartrate Injection?

The duration of the anesthetic effect can vary but is typically extended by the inclusion of adrenaline. It can provide localized anesthesia for a longer period compared to lignocaine alone.

  1. What are the potential side effects of this injection?

Common side effects may include numbness, tingling, or swelling at the injection site. Cardiovascular side effects like increased heart rate and elevated blood pressure can occur due to the adrenaline component. Central nervous system side effects are rare but possible.

  1. Is this injection safe for emergency situations, such as allergic reactions or cardiac arrest?

Yes, Lignocaine Hydrochloride & Adrenaline Bitartrate Injection, when administered by trained healthcare professionals, can be used in emergency situations like severe allergic reactions (anaphylaxis) or cardiac arrest to help improve blood pressure and blood flow.

  1. How is the dosage determined for this injection?

Dosage is determined based on the specific procedure, the patient’s weight, and other factors. Healthcare professionals calculate the appropriate dose to achieve effective anesthesia while minimizing potential side effects.

  1. Can patients with allergies receive this injection safely?

Patients with known allergies to lignocaine, adrenaline, or related substances should inform their healthcare provider before receiving this injection. Allergic reactions can occur, although they are relatively rare.

  1. Is this injection suitable for children or pregnant women?

The use of this injection in children and pregnant women should be carefully considered and determined by a healthcare provider based on the specific situation, potential benefits, and risks.

Always consult with a qualified healthcare provider for personalized information and guidance regarding Lignocaine Hydrochloride & Adrenaline Bitartrate Injection, as individual circumstances and medical needs may vary.

As Lignocaine Hydrochloride & Adrenaline Bitartrate Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Lignocaine Hydrochloride & Adrenaline Bitartrate Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Lignocaine Hydrochloride & Adrenaline Bitartrate Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Lignocaine Hydrochloride & Adrenaline Bitartrate Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274