GENERIC NAME OF THE MEDICINAL PRODUCT:

A. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 0.5mg/500mg
B. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 0.5mg/1000mg
C. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 1mg/500mg
D. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 1mg/850mg
E. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 1mg/1000mg
F. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/500mg
G. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/850mg
H. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/1000mg
I. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 3mg/500mg
J. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 3mg/850mg
K. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 3mg/1000mg
L. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 4mg/500mg
M. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 4mg/1000mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

A. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 0.5mg/500mg
Each uncoated tablet contains:
Glimepiride IP……………………….0.5mg
Metformin Hydrochloride IP………….500mg
(In sustained release form)
Excipients…………………………………...q.s.

B. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 0.5mg/1000mg
Each uncoated tablet contains:
Glimepiride IP……………………….0.5mg
Metformin Hydrochloride IP………….1000mg
(In sustained release form)
Excipients…………………………………...q.s.

C. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 1mg/500mg
Each uncoated tablet contains:
Glimepiride IP……………………….1mg
Metformin Hydrochloride IP………….500mg
(In sustained release form)
Excipients…………………………………...q.s.

D. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 1mg/850mg
Each uncoated tablet contains:
Glimepiride IP……………………….1mg
Metformin Hydrochloride IP………….850mg
(In sustained release form)
Excipients…………………………………...q.s.

E. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 1mg/1000mg
Each uncoated tablet contains:
Glimepiride IP……………………….1mg
Metformin Hydrochloride IP………….1000mg
(In sustained release form)
Excipients…………………………………...q.s.

F. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/500mg
Each uncoated tablet contains:
Glimepiride IP……………………….2mg
Metformin Hydrochloride IP………….500mg
(In sustained release form)
Excipients…………………………………...q.s.

G. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/850mg
Each uncoated tablet contains:
Glimepiride IP……………………….2mg
Metformin Hydrochloride IP………….850mg
(In sustained release form)
Excipients…………………………………...q.s.

H. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/1000mg
Each uncoated tablet contains:
Glimepiride IP……………………….2mg
Metformin Hydrochloride IP………….1000mg
(In sustained release form)
Excipients…………………………………...q.s.


I. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 3mg/500mg
Each uncoated tablet contains:
Glimepiride IP……………………….3mg
Metformin Hydrochloride IP………….500mg
(In sustained release form)
Excipients…………………………………...q.s.

J. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 3mg/850mg
Each uncoated tablet contains:
Glimepiride IP……………………….3mg
Metformin Hydrochloride IP………….850mg
(In sustained release form)
Excipients…………………………………...q.s.

K. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 3mg/1000mg
Each uncoated tablet contains:
Glimepiride IP……………………….3mg
Metformin Hydrochloride IP………….1000mg
(In sustained release form)
Excipients…………………………………...q.s.

L. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 4mg/500mg
Each uncoated tablet contains:
Glimepiride IP……………………….4mg
Metformin Hydrochloride IP………….500mg
(In sustained release form)
Excipients…………………………………...q.s.

M. Glimepiride and Metformin Hydrochloride Sustained Release Tablets 4mg/1000mg
Each uncoated tablet contains:
Glimepiride IP……………………….4mg
Metformin Hydrochloride IP………….1000mg
(In sustained release form)
Excipients…………………………………...q.s.

THERAPEUTIC INDICATIONS:

Glimepiride & Metformin is used for the treatment of type 2 diabetes mellitus, when diet, exercise and glimepiride or metformin alone is unable to control your blood sugar levels adequately.

CAUTION & SCHEDULE:

CAUTION: The tablet should not be broken crushed or chewed and swallowed whole.
Read enclosed leaflet before use.
SCHEDULE “H” Prescription Drug -Warning: Not to be sold by retail without the prescription of a Registered Medical Prescriber.
KEEP MEDICINE OUT OF REACH OF CHILDREN.

STORAGE & DOSAGE:

Storage: Protect form moisture at a temperature not exceeding 30˚C.
Do not freeze.
Keep the container tightly closed in order to protect from moisture.
Dosage: As directed by the Physician.

Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/1000mg Technical Specification:

Product Name:
Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/1000mg
Brand Name:Glucotaj MET SR
Strength:0.5mg/500mg, 0.5mg/1000mg,
1mg/500mg, 1mg/850mg, 1mg/1000mg,
2mg/500mg, 2mg/850mg, 2mg/1000mg,
3mg/500mg, 3mg/850mg, 3mg/1000mg,
4mg/500mg, 4mg/1000mg
Dosage Form:Tablets (un-coated)
Route of Administration:Via Oral Route
Packing:10s, 15s, 100s, 150s
Pack Insert/Leaflet:PIL (Patient Information Leaflet)
Regulatory Documents:COA, MOA, Stability Studies, GMP
Therapeutic use:Anti-diabetic, sulfonylureas
Indication: Glimepiride & Metformin is used for the treatment of type 2 diabetes mellitus, when diet, exercise and glimepiride or metformin alone is unable to control your blood sugar levels adequately.
Storage:Protect form moisture at a temperature not exceeding 30˚C.Do not freeze. Keep the container tightly closed in order to protect from moisture.

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/1000mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Glimepiride and Metformin Hydrochloride Sustained Release Tablets 2mg/1000mg
    Each uncoated tablet contains:
    Glimepiride IP……………………….2mg
    Metformin Hydrochloride IP………….1000mg
    (In sustained release form)
    Excipients……………………………………q.s.

THERAPEUTIC INDICATIONS:

Glimepiride & Metformin is used for the treatment of type 2 diabetes mellitus, when diet, exercise and glimepiride or metformin alone is unable to control your blood sugar levels adequately.

CAUTION & SCHEDULE:

CAUTION:  The tablet should not be broken crushed or chewed and swallowed whole.

Read enclosed leaflet before use.

SCHEDULE “H” Prescription Drug -Warning:  Not to be sold by retail without the prescription of a Registered Medical Prescriber.

Keep medicine out of reach of children.

STORAGE & DOSAGE:

Storage:  Protect form moisture at a temperature not exceeding 30˚C.  Do not freeze.  Keep the container tightly closed in order to protect from moisture.

Dosage:  As directed by the Physician.

Why Taj Pharmaceuticals?

The unparalleled advantages of choosing Taj Pharma for your Glimepiride and Metformin Hydrochloride Sustained Release Tablets. Our commitment to excellence in diabetes management is evident in every aspect of our pharmaceutical solutions.

  • Quality Assurance: At Taj Pharma, we prioritize your well-being. Our Glimepiride and Metformin Hydrochloride Sustained Release Tablets are manufactured under strict quality standards, ensuring their safety, efficacy, and reliability. Your health is our top priority.
  • Affordability: We believe that access to quality diabetes medications should never be a barrier to your health. Taj Pharma offers competitive pricing, making these essential medications affordable and within reach for all individuals managing diabetes.
  • Innovative Formulations: Our legacy of innovation continues with our sustained release tablets. These advanced formulations provide steady and controlled release of Glimepiride and Metformin, helping you maintain stable blood sugar levels throughout the day.
  • Trustworthy Partner: Taj Pharma has a track record of reliability and excellence in the pharmaceutical industry. Our Glimepiride and Metformin Hydrochloride Sustained Release Tablets are trusted by healthcare professionals and patients alike for effective diabetes management.
  • Comprehensive Diabetes Care: We understand that managing diabetes involves more than just medication. Taj Pharma is dedicated to providing comprehensive support, including educational resources and lifestyle guidance, to empower you on your journey to better health.

Choose Taj Pharma for Glimepiride and Metformin Hydrochloride Sustained Release Tablets that not only manage your diabetes effectively but also prioritize your well-being. We’re here to support you every step of the way in your quest for a healthier, more fulfilling life. Your health, your choice, choose Taj Pharma.

What is Glimepiride and Metformin Hydrochloride Sustained Release Tablets and its use?

Glimepiride and Metformin Hydrochloride Sustained Release Tablets are a combination medication used to manage high blood sugar levels in individuals with type 2 diabetes. This medication combines two active ingredients, Glimepiride and Metformin Hydrochloride, in a sustained-release tablet form. Here’s an overview of Glimepiride and Metformin Hydrochloride Sustained Release Tablets and their use:

  • Glimepiride: Glimepiride is an oral antidiabetic medication belonging to the class of drugs known as sulfonylureas. It works by stimulating the pancreas to release insulin, a hormone that helps regulate blood sugar levels. Glimepiride is effective in lowering blood sugar levels, particularly after meals when blood sugar tends to rise.
  • Metformin Hydrochloride: Metformin is an oral antidiabetic medication classified as a biguanide. It works by reducing the production of glucose in the liver and improving the body’s sensitivity to insulin. Metformin helps lower fasting blood sugar levels and reduces insulin resistance, making it an essential component of diabetes management.
  • Sustained Release Formulation: Glimepiride and Metformin Hydrochloride Sustained Release Tablets are designed to release these medications gradually over an extended period. This controlled release ensures that the drugs have a prolonged effect, maintaining more stable blood sugar levels throughout the day.
  • Use: Glimepiride and Metformin Hydrochloride Sustained Release Tablets are typically prescribed for individuals with type 2 diabetes who have not achieved adequate blood sugar control with diet and exercise alone. They are used to:
    1) Lower and maintain blood sugar levels within the target range.
    2) Improve insulin sensitivity and reduce insulin resistance.
    3) Minimize the risk of diabetes-related complications by controlling blood sugar levels.
  • Combination Therapy: Combining Glimepiride and Metformin in a single tablet offers several advantages. Glimepiride stimulates insulin release, while Metformin addresses insulin resistance and excessive glucose production. Together, they provide comprehensive blood sugar control.
  • Dosage: The dosage of Glimepiride and Metformin Hydrochloride Sustained Release Tablets varies depending on the individual’s specific needs, medical history, and blood sugar levels. It is essential to follow your healthcare provider’s prescribed dosage and instructions for optimal results.
  • Lifestyle Management: Alongside medication, lifestyle modifications, including a balanced diet and regular physical activity, are crucial components of diabetes management. Your healthcare provider will likely recommend a comprehensive plan to help you manage your condition effectively.

It’s essential to use Glimepiride and Metformin Hydrochloride Sustained Release Tablets as prescribed by your healthcare provider and attend regular check-ups to monitor your blood sugar levels and assess your response to the medication. These tablets are just one part of a comprehensive approach to managing type 2 diabetes and should be used in conjunction with other healthy lifestyle practices.

How Does Glimepiride and Metformin Hydrochloride Sustained Release Tablets work?

Glimepiride and Metformin Hydrochloride Sustained Release Tablets work through the combined actions of their two active ingredients, Glimepiride and Metformin Hydrochloride, to help regulate blood sugar levels in individuals with type 2 diabetes. Here’s how each component works:

  • Glimepiride (Sulfonylurea):
    Stimulates Insulin Release: Glimepiride belongs to the class of drugs known as sulfonylureas. It acts by stimulating the beta cells in the pancreas to release insulin. Insulin is a hormone that plays a crucial role in regulating blood sugar levels by facilitating the uptake of glucose into cells.
    Reduces Blood Sugar Levels: By promoting insulin secretion, Glimepiride helps lower elevated blood sugar levels, particularly after meals (postprandial hyper glycemia). This action is especially beneficial for people with type 2 diabetes who still have functioning beta cells.
  • Metformin Hydrochloride (Biguanide):
    Decreases Liver Glucose Production: Metformin works primarily by reducing the production of glucose (sugar) in the liver. In people with type 2 diabetes, the liver can overproduce glucose, contributing to elevated blood sugar levels. Metformin helps suppress this excess glucose production.
    Improves Insulin Sensitivity: Metformin also enhances insulin sensitivity in peripheral tissues, such as muscle cells. This means that cells become more responsive to the effects of insulin, allowing them to take up glucose more efficiently from the bloodstream.
    Reduces Absorption of Glucose: Metformin may decrease the absorption of glucose from the digestive tract, further contributing to lower blood sugar levels.
  • Sustained Release Formulation:
    The sustained release formulation of Glimepiride and Metformin Hydrochloride in tablet form is designed to provide a controlled and prolonged release of these medications in the body. This controlled release ensures that the drugs have a sustained effect throughout the day, helping to maintain more stable blood sugar levels.
  • Combination Therapy:
    Combining Glimepiride and Metformin Hydrochloride in a single tablet provides a comprehensive approach to blood sugar control. Glimepiride addresses post meal spikes in blood sugar, while Metformin addresses fasting and overall glucose regulation. This combination is particularly useful for individuals with type 2 diabetes who may require more than one mode of action to achieve optimal blood sugar management.

Benefits of Glimepiride and Metformin Hydrochloride Sustained Release Tablets:

  • Comprehensive Blood Sugar Control: The combination of Glimepiride and Metformin addresses different aspects of blood sugar regulation. Glimepiride stimulates insulin release to lower post-meal blood sugar spikes, while Metformin reduces liver glucose production and improves insulin sensitivity for overall glycemic control.
  • Sustained Release: These tablets are formulated for sustained release, providing a prolonged effect throughout the day. This helps maintain more stable blood sugar levels, reducing the risk of extreme highs and lows.
  • Convenience: Combining two medications into one tablet simplifies the treatment regimen for individuals with type 2 diabetes. This can lead to better adherence to the prescribed therapy.
  • Reduction in Insulin Resistance: Metformin, one of the components, helps improve insulin sensitivity in peripheral tissues, which can lead to better utilization of insulin and improved blood sugar control.
  • Lowering Risk of Complications: Effective blood sugar control with Glimepiride and Metformin can reduce the risk of diabetes-related complications, such as cardiovascular disease, kidney problems, and neuropathy.

Side Effects of Glimepiride and Metformin Hydrochloride Sustained Release Tablets:

  • Gastrointestinal Symptoms: These can include nausea, diarrhea, abdominal discomfort, and flatulence. These side effects are more commonly associated with Metformin and often occur when treatment is initiated. They tend to improve over time.
  • Hypoglycemia (Low Blood Sugar): Glimepiride can cause hypoglycemia, especially if not taken with food or if the dose is too high. Symptoms of hypoglycemia may include shakiness, dizziness, sweating, confusion, and rapid heartbeat.
  • Weight Gain: Some individuals may experience weight gain while taking Glimepiride, although it is generally less likely than with some other diabetes medications.
  • Vitamin B12 Deficiency: Long-term use of Metformin may be associated with a decreased absorption of vitamin B12, potentially leading to a deficiency. Regular monitoring of vitamin B12 levels may be necessary.
  • Lactic Acidosis (Rare): While extremely rare, Metformin can lead to a serious condition called lactic acidosis. Symptoms may include muscle pain, weakness, difficulty breathing, and severe fatigue. Seek immediate medical attention if these symptoms occur.
  • Allergic Reactions (Rare): In very rare cases, individuals may experience allergic reactions to Glimepiride or Metformin. Symptoms can include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical help if such reactions occur.

Frequently Asked Questions about Glimepiride and Metformin Hydrochloride Sustained Release Tablets:

  1. What are Glimepiride and Metformin Hydrochloride Sustained Release Tablets?

Glimepiride and Metformin Hydrochloride Sustained Release Tablets are a combination medication used to treat type 2 diabetes. They contain two active ingredients, Glimepiride and Metformin, in a single tablet.

  1. How do these tablets work to lower blood sugar levels?

Glimepiride stimulates the release of insulin from the pancreas, while Metformin reduces liver glucose production and improves insulin sensitivity in peripheral tissues. Together, they help regulate blood sugar levels.

  1. Who is prescribed Glimepiride and Metformin Hydrochloride Sustained Release Tablets?

These tablets are typically prescribed for individuals with type 2 diabetes whose blood sugar levels are not adequately controlled with lifestyle changes (diet and exercise) alone.

  1. Are there any lifestyle changes I should make while taking these tablets?

Yes, maintaining a healthy lifestyle is essential for managing diabetes. Your healthcare provider may recommend dietary changes, regular exercise, and weight management alongside medication.

  1. Can I drink alcohol while taking Glimepiride and Metformin Hydrochloride Sustained Release Tablets?

It’s best to limit alcohol consumption as it can affect blood sugar levels and increase the risk of hypoglycemia (low blood sugar). Consult your healthcare provider for guidance on alcohol use.

  1. What should I do if I miss a dose of these tablets?

If you miss a dose, take it as soon as you remember, unless it’s close to the next scheduled dose. Do not double the dose. Follow your healthcare provider’s instructions for missed doses.

  1. Are there any common side effects of Glimepiride and Metformin Hydrochloride Sustained Release Tablets?

Common side effects can include gastrointestinal symptoms like nausea and diarrhea, as well as a potential risk of hypoglycemia (low blood sugar) with Glimepiride.

  1. Can these tablets cause weight gain?

Glimepiride may cause weight gain in some individuals, but it is generally less likely compared to some other diabetes medications.

  1. How long does it take for these tablets to start working?

The onset of action can vary, but you may start to see improvements in your blood sugar levels within a few days to weeks of starting treatment. However, it’s essential to continue taking the medication as prescribed.

  1. Can I take other medications while using Glimepiride and Metformin Hydrochloride Sustained Release Tablets?

Inform your healthcare provider about all the medications, including over-the-counter and herbal supplements, you are taking. Some drugs may interact with Glimepiride or Metformin.

  1. Is it safe to use these tablets during pregnancy or breastfeeding?

Discuss the risks and benefits with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Your provider will help determine the best approach to managing your diabetes during these times.

As Glimepiride and Metformin Hydrochloride Sustained Release Tablets Exporters; We can cater to export business queries from the following geographies. We are exporting our Glimepiride and Metformin Hydrochloride Sustained Release Tablets product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Glimepiride and Metformin Hydrochloride Sustained Release Tablets Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Glimepiride and Metformin Hydrochloride Sustained Release Tablets, Taj Pharmaceuticals Limited to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274