GENERIC NAME OF MEDICINAL PRODUCT:

(A) Furosemide Injection USP 20mg/2mL (10mg/ml)
(B) Furosemide Injection USP 40mg/4mL (10mg/ml)
(C) Furosemide Injection USP 100mg/10mL (10mg/ml)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

(A) Furosemide Injection USP 20mg/2mL (10mg/ml)
Each ml contains:
Furosemide USP……………….10mg
Water for injections USP……………………. q. s


(B) Furosemide Injection USP 40mg/4mL (10mg/ml)
Each ml contains:
Furosemide USP……………….10mg
Water for injections USP……………………. q. s

(C) Furosemide Injection USP 100mg/10mL (10mg/ml)
Each ml contains:
Furosemide USP……………….10mg
Water for injections USP……………………. q. s

THERAPEUTIC INDICATION:

Furosemide injection is used to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease (cirrhosis), kidney disease, or other medical conditions. It is also used to control mild to moderate high blood pressure.

CAUTION & WARNING:

CAUTION: If any foreign particle is visible, please do not use the solution & return for replacement.
KEEP OUT OF REACH OF CHILDREN.
Discard any unused portion.
WARNING: Not to be sold by retail without the prescription of Registered Medical Practitioner.

STORAGE & DOSAGE:

Storage: Store at 20°C to 25°C (68° to 77°). See USP controlled room temperature.
Dosage: As directed by Physician.

Furosemide Injection USP 20mg/2mL (10mg/ml) Technical Specification:

Product Name:Furosemide Injection USP
Brand Name:(Frusotaj)
Strength:20mg/2mL (10mg/ml)40mg/4mL (10mg/ml), 100mg/10mL (10mg/ml)
Dosage Form:Liquid Injection (Sterile) *Non-pyrogenic
Packing:2ml Ampoule, 2ml, 4ml 10 mL vial (SINGLE-DOSE)
Route of Administration:For IM/slow IV use.
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Diuretics, Anti-hypertensive, Fluid retention
Indication: Furosemide injection is used to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease (cirrhosis), kidney disease, or other medical conditions. It is also used to control mild to moderate high blood pressure.
Storage:Store at 20°C to 25°C (68° to 77°). See USP-controlled room temperature.

GENERIC NAME OF MEDICINAL PRODUCT:

  • Furosemide Injection USP 20mg/2mL (10mg/ml)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Furosemide Injection USP 20mg/2mL (10mg/ml)
    Each ml contains:
    Furosemide USP……………….10mg
    Water for injections USP……………………. q. s   

THERAPEUTIC INDICATION:

Furosemide injection is used to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease (cirrhosis), kidney disease, or other medical conditions. It is also used to control mild to moderate high blood pressure.

CAUTION & WARNING:

CAUTION: If any foreign particle is visible, please do not use the solution & return for a replacement.
KEEP OUT OF REACH OF CHILDREN.
Discard any unused portion.
WARNING: Not to be sold by retail without the prescription of a Registered Medical Practitioner.

STORAGE & DOSAGE:

Storage: Store at 20°C to 25°C (68° to 77°).
See USP-controlled room temperature.
Dosage: As directed by the Physician.

Why Taj Pharmaceuticals?

Taj Pharmaceuticals stands out as a preferred choice for Furosemide Injection for several compelling reasons. Foremost, Taj Pharmaceuticals is known for its steadfast commitment to upholding rigorous standards of quality in pharmaceutical production. This commitment is particularly critical for injectable medications like Furosemide, which are administered directly into the bloodstream. The emphasis on quality assurance instills confidence among healthcare providers and patients, ensuring the medication’s effectiveness and safety. With a wealth of experience in the pharmaceutical industry, Taj Pharmaceuticals has garnered valuable expertise in the manufacturing and distribution of a diverse range of pharmaceutical products. This extensive experience contributes to the consistency and reliability of their pharmaceutical offerings, solidifying their reputation as a trusted supplier.

Taj Pharmaceuticals places a strong emphasis on compliance with stringent regulatory standards and quality control procedures. This dedication to compliance ensures that Furosemide Injection meets the necessary quality and safety requirements set by regulatory authorities. Healthcare providers can trust that the medication complies with all necessary regulations, further enhancing patient safety. The global reach and distribution network of Taj Pharmaceuticals are noteworthy strengths. This ensures the availability of Furosemide and other pharmaceutical products to healthcare providers and patients across various regions. This global reach enhances accessibility and patient care on an international scale, making essential medications readily available when needed. Furthermore, Taj Pharmaceuticals demonstrates a commitment to research and development (R&D), a cornerstone of pharmaceutical innovation. Investment in R&D may result in the development of more effective and advanced formulations of Furosemide, potentially enhancing its therapeutic benefits.

Reliability in supply is paramount to ensure that healthcare institutions and patients have consistent access to essential medications. Taj Pharmaceuticals’ commitment to supply chain management contributes to the dependable availability of Furosemide Injection, ensuring that it remains accessible when required. In consideration of affordability, Taj Pharmaceuticals may offer competitive pricing options, making Furosemide Injection more affordable and accessible to healthcare institutions and patients. This commitment aligns with the goal of ensuring access to essential medications without imposing financial barriers. Lastly, Taj Pharmaceuticals places patient well-being and safety at the forefront of its priorities. This aligns with the importance of Furosemide, a medication used to manage conditions such as edema and hypertension. Their dedication to patient safety reinforces the trust placed in their products by healthcare providers and patients alike. In conclusion, Taj Pharmaceuticals’ dedication to quality, compliance, research, affordability, and patient support makes it a compelling choice for healthcare providers seeking a reliable supplier for Furosemide Injection and other pharmaceutical needs. Their unwavering focus on patient safety aligns seamlessly with the significance of this medication in managing fluid retention and hypertension, ultimately benefiting patient care and outcomes.

What is Furosemide Injection and its uses:

Furosemide Injection is a medication that belongs to a class of drugs known as loop diuretics. It is administered intravenously (injection) and is used for several medical purposes, primarily related to its diuretic (water-excreting) properties. Here are its key uses:

  • Edema: Furosemide Injection is commonly prescribed to treat edema, which is the abnormal accumulation of fluid in various parts of the body, often observed in conditions like congestive heart failure, kidney dysfunction, liver disease, or severe peripheral edema. By increasing urine production, Furosemide helps reduce excess fluid, relieving symptoms of swelling and discomfort.
  • Congestive Heart Failure (CHF): In the management of congestive heart failure, Furosemide is used to alleviate fluid retention and reduce the workload on the heart. By promoting the removal of excess fluid from the body, it can help improve breathing difficulties and decrease the strain on the heart.
  • Hypertension (High Blood Pressure): Furosemide may be used in cases of severe or resistant hypertension when other anti-hypertensive medications are ineffective on their own. It helps lower blood pressure by reducing blood volume through increased urine output.
  • Acute Pulmonary Edema: Furosemide Injection is sometimes administered in emergency situations, such as acute pulmonary edema (fluid buildup in the lungs), to rapidly relieve symptoms and improve oxygenation.
  • Hypercalcemia: Furosemide can aid in the management of hypercalcemia, a condition characterized by elevated levels of calcium in the blood. It promotes the excretion of excess calcium through urine.
  • Kidney Dysfunction: In some cases of kidney dysfunction or renal impairment, Furosemide may be used to help maintain or restore normal fluid and electrolyte balance in the body.
  • Diagnostic Testing: Furosemide may also be used in certain diagnostic tests, such as renal scans or nuclear medicine studies, to enhance visualization of the urinary tract.

It’s important to note that Furosemide Injection is a potent diuretic and should be used under the supervision and guidance of a qualified healthcare provider. The dosage and administration of Furosemide depend on the specific medical condition, the patient’s fluid and electrolyte status, and other individual factors. Healthcare providers will determine the most appropriate use of Furosemide Injection to ensure optimal therapeutic outcomes.

How Does Furosemide Injection Work?

Furosemide Injection works by affecting the functioning of the kidneys and the reabsorption of electrolytes and water in the renal tubules. Here’s how it works:

  • Inhibition of Sodium and Chloride Reabsorption: Furosemide is a loop diuretic, which means it primarily acts on a part of the kidney called the loop of Henle. In the loop of Henle, sodium (Na+) and chloride (Cl-) ions are actively reabsorbed from the urine into the bloodstream. This process normally results in the concentration of urine and the reabsorption of water.
  • Blockade of the Sodium-Potassium-Chloride Co-Transporter: Furosemide works by inhibiting a specific transporter protein called the sodium-potassium-chloride co-transporter (NKCC2) in the cells of the thick ascending limb of the loop of Henle. By inhibiting this transporter, Furosemide prevents the reabsorption of sodium, chloride, and potassium ions from the urine back into the blood.
  • Increased Urine Output: As a result of this inhibition, a larger amount of sodium, chloride, and potassium ions remain in the urine rather than being reabsorbed. This creates an osmotic gradient that draws water into the urine, increasing the volume of urine produced by the kidneys. This increased urine output is what makes Furosemide a potent diuretic or “water pill.”
  • Reduction of Blood Volume and Blood Pressure: By increasing urine output and reducing the reabsorption of sodium and water, Furosemide decreases blood volume. This reduction in blood volume subsequently leads to a decrease in blood pressure, making it an effective medication for managing conditions like hypertension (high blood pressure) and edema (fluid retention).
  • Electrolyte Imbalance: It’s important to note that while Furosemide helps eliminate excess sodium and water, it can also lead to the loss of potassium and other electrolytes in the urine. To prevent electrolyte imbalances, healthcare providers may monitor potassium levels and prescribe potassium supplements or potassium-sparing diuretics as necessary.

Overall, Furosemide Injection is a powerful diuretic that enhances the excretion of sodium, chloride, and water from the body, effectively reducing fluid volume and helping manage conditions associated with fluid retention and elevated blood pressure. Its rapid onset of action is particularly valuable in clinical situations where prompt diuresis is required.

Benefits of Furosemide Injection:

  • Edema Management: Furosemide Injection is highly effective in reducing edema (fluid retention) associated with conditions such as congestive heart failure, kidney dysfunction, liver disease, and peripheral edema. By increasing urine output, it helps alleviate swelling and discomfort caused by excess fluid buildup.
  • Congestive Heart Failure (CHF): Furosemide is a cornerstone in the management of congestive heart failure. It reduces fluid overload, which is common in CHF patients, leading to improved cardiac function and symptom relief.
  • Blood Pressure Control: Furosemide may be used to lower blood pressure in cases of severe or resistant hypertension. By promoting diuresis and reducing blood volume, it contributes to blood pressure regulation.
  • Acute Pulmonary Edema: Furosemide Injection is crucial in emergency situations like acute pulmonary edema, where rapid removal of excess fluid from the lungs is essential to improve oxygenation and alleviate breathing difficulties.
  • Hypercalcemia Management: Furosemide can assist in treating hypercalcemia (high blood calcium levels) by enhancing the excretion of excess calcium through urine.
  • Kidney Dysfunction: In cases of kidney dysfunction, Furosemide can help restore or maintain fluid and electrolyte balance by promoting diuresis.

Side Effects of Furosemide Injection:

  • 1. Electrolyte Imbalances: Furosemide can lead to the loss of important electrolytes like potassium, sodium, magnesium, and calcium in the urine. This may result in conditions such as hypokalemia (low potassium), hyponatremia (low sodium), and others. Monitoring electrolyte levels is essential, and supplements may be prescribed as needed.
  • Dehydration: Excessive diuresis can lead to dehydration, especially in vulnerable populations such as the elderly. Monitoring for signs of dehydration, such as dry mouth, extreme thirst, and dark urine, is important.
  • Hypotension: Furosemide can cause a drop in blood pressure, which may lead to symptoms like dizziness or lightheadedness, especially when standing up quickly. Patients should be cautious when changing positions.
  • Ototoxicity: Rarely, Furosemide can have an adverse effect on hearing (ototoxicity), causing ringing in the ears (tinnitus) or hearing loss. This is more likely with high doses or prolonged use.
  • Allergic Reactions: Although rare, allergic reactions to Furosemide can occur, presenting as skin rash, itching, swelling, or more severe allergic responses. Immediate medical attention is necessary if a severe allergic reaction occurs.
  • Gastrointestinal Disturbances: Furosemide may cause gastrointestinal side effects such as nausea, vomiting, and diarrhea.
  • Blood Glucose Changes: Furosemide can affect blood glucose levels, potentially leading to hyperglycemia (high blood sugar) in some individuals.
  • Kidney Function: In some cases, Furosemide may exacerbate kidney dysfunction, especially if used in individuals with pre-existing kidney problems.

It’s important to recognize that Furosemide Injection should be used under the supervision of a healthcare provider who can closely monitor its effects and adjust the dosage as needed. The benefits of fluid removal and blood pressure control must be balanced against the potential side effects and risks. Individual patient factors and medical conditions will influence the use and monitoring of this medication.

Frequently Asked Questions About Furosemide Injection:

Certainly, here are some frequently asked questions (FAQs) about Furosemide Injection:

  1. What is Furosemide Injection used for?

Furosemide Injection is primarily used to treat conditions associated with fluid retention, such as edema (swelling) due to heart failure, kidney dysfunction, liver disease, and acute pulmonary edema. It is also sometimes used to lower blood pressure in specific cases of hypertension.

  1. How does Furosemide Injection work?

Furosemide is a diuretic medication that works by inhibiting the reabsorption of sodium and chloride ions in the kidney’s tubules. This leads to increased urine production and the removal of excess fluid from the body.

  1. Is Furosemide Injection the same as oral Furosemide tablets?

While both are forms of Furosemide, Furosemide Injection is administered directly into the bloodstream and is typically used in situations where rapid diuresis is required, such as in acute pulmonary edema. Oral Furosemide tablets are taken by mouth and have a slower onset of action.

  1. How quickly does Furosemide Injection work?

Furosemide Injection has a rapid onset of action, with diuresis typically occurring within minutes to an hour after administration.

  1. Are there any special considerations when using Furosemide Injection in emergency situations, such as acute pulmonary edema?

In emergencies, Furosemide Injection may be administered intravenously to rapidly alleviate fluid buildup in the lungs. It is essential to monitor vital signs and electrolyte levels closely during and after administration.

  1. Can Furosemide cause electrolyte imbalances?

Yes, Furosemide can lead to the loss of electrolytes, such as potassium, sodium, magnesium, and calcium, in the urine. Monitoring electrolyte levels and prescribing supplements when necessary is important to prevent imbalances.

  1. Is Furosemide Injection safe during pregnancy and breastfeeding?

The use of Furosemide during pregnancy and breastfeeding should be carefully considered and supervised by a healthcare provider. It may be used if the potential benefits outweigh the risks, but close monitoring is essential.

  1. Can Furosemide cause hearing problems?

Furosemide can rarely cause ototoxicity, which includes symptoms like tinnitus (ringing in the ears) or hearing loss. This risk may be higher with high doses or prolonged use.

  1. Are there any drug interactions with Furosemide?

Furosemide may interact with other medications, including certain antibiotics, antihypertensive drugs, and nonsteroidal antiinflammatory drugs (NSAIDs). Healthcare providers should be aware of all medications a patient is taking to prevent potential interactions.

  1. Can Furosemide be used for weight loss purposes?

Furosemide should not be used for weight loss, as its primary purpose is to treat medical conditions involving fluid retention. Using it for weight loss without a medical indication can lead to dangerous side effects and electrolyte imbalances.

These FAQs provide valuable information about Furosemide Injection, its uses, and considerations for its safe and effective use. Patients should always consult with a healthcare provider for personalized guidance regarding this medication.

As Furosemide Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Furosemide Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Furosemide Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Furosemide Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274