GENERIC NAME OF THE MEDICINAL PRODUCT:

A. Doxorubicin Hydrochloride Injection BP 50mg
B. Doxorubicin Hydrochloride Injection BP 10mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

1. Doxorubicin Hydrochloride Injection BP 50mg
Each Vial contains:
Doxorubicin Hydrochloride BP……….50mg
Excipients………………………………………...q. s


2. Doxorubicin Hydrochloride Injection BP 10mg
Each Vial contains:
Doxorubicin Hydrochloride BP……….10mg
Excipients………………………………………...q. s

THERAPEUTIC INDICATIONS:

Doxorubicin is also indicated for the treatment of cancers of the ovary, prostate, stomach, and thyroid; small cell cancer of the lung, and liver; squamous cell cancer of the head and neck; multiple myeloma, Hodgkin's disease, lymphomas, acute lymphocytic leukemia (ALL), and acute myeloid leukemia (AML).

DIRECTION OF USE:

To be reconstituted with 25ml or 5ml by adding Sterile Water for Injection BP or 0.9% Sodium Chloride or 5% Dextrose in Sterile Water for Injection to give final concentration of 2mg/ml.
After reconstitution the solution is stable for 7 days at room temperature and 15 days at 2°C to 8°C.
Use immediately after reconstitution.

CAUTION & WARNING:

CAUTION: Do not use the injection if the contents are not clear or contains visible particulate matter after reconstitution.
CYTOTOXIX-DISPOSE OF PROPERLY
Do not pool unused portion from the vials. Do not administer more than one dose from a vial.
Warning: Cytotoxic agent: Not to be sold by retail without the prescription of a Registered Medical Practitioner/ Cancer Hospital only.
It is dangerous to take this preparation except under Medical Supervision.

STORAGE & DOSAGE:

Storage: Store at a temperature not exceeding 30°C.
Protect from light.
Do not freeze.
Please refer product insert for more information.
KEEP MEDICINE OUT OF REACH OF CHILDREN.
FLIP-OFF SEAL IS PROVIDED FOR TEMPER EVIDENCE
Dosage: As directed by an Oncologist.

Doxorubicin Hydrochloride Injection BP 50mg Manufacturers, Suppliers in India:

Taj Pharmaceuticals has firmly established itself as a distinguished manufacturer of Doxorubicin Hydrochloride Injection BP 50mg within India, showcasing a strong commitment to delivering products of exceptional quality. Operating under the banner of Taj Pharma, our company has garnered extensive experience in the specialized production of Doxorubicin Hydrochloride Injection BP 50mg, a testament to our dedication to precision and excellence. Doxorubicin hydrochloride, a pivotal component of chemotherapy, functions as an antibiotic that exerts its effects by impeding or retarding the advancement of cancer cells and rapidly dividing cells. By causing damage to their DNA, this potent medication curtails their growth. Recognized as a cytotoxic anthracycline and topoisomerase II inhibitors, Doxorubicin Hydrochloride assumes a critical role in multi-agent adjuvant chemotherapy. Specifically, it aids in the treatment of women with axillary lymph node involvement subsequent to the surgical removal of primary breast cancer. The application of Doxorubicin hydrochloride extends to the treatment of specific metastatic diseases, leukemia, and lymphoma, underscoring its versatility in oncology.

Within the realm of pharmaceutical excellence, Taj Pharmaceuticals holds a distinguished position. Our company not only operates as a manufacturer but also a trusted supplier of Doxorubicin Hydrochloride Injection BP 50mg in India. This preference stems from our unwavering commitment to upholding elevated standards and ensuring the consistent delivery of products exhibiting uncompromising quality. Taj Pharma, acclaimed for its prowess as a Doxorubicin Hydrochloride Injection BP 50mg manufacturer in India, remains steadfast in upholding the highest standards and adhering to stringent regulatory requirements. Our unwavering dedication is reflected in our comprehensive quality control protocols, assuring a uniform standard for every batch of medicine that bears our name.

The manufacturing processes of Doxorubicin Hydrochloride Injection BP 50mg at Taj Pharma meticulously align with the esteemed BP standards. This adherence underscores our commitment to offering products that meet globally recognized benchmarks of quality. Moreover, the active ingredients utilized in Taj Pharma’s injections exemplify the company’s commitment to international standards, reminiscent of those upheld by European pharmaceutical products. Taj Pharmaceuticals, through its meticulous approach to production, adherence to international standards, and dedication to innovation, emerges as a cornerstone in the realm of pharmaceutical solutions, with Doxorubicin Hydrochloride Injection BP 50mg serving as a testament to its unwavering pursuit of excellence in healthcare.

Doxorubicin Hydrochloride for Injection BP 50mg Technical Specification:

Product Name:Doxorubicin Hydrochloride for Injection BP 50mg
Brand Name:DOXOTAJ
Strength:50mg,10mg
Dosage Form:Lyophilised Powder Injection (Sterile) *Preservative-free
Packing:Single dose Vial
Route of Administration:For I.V. use only (After dilution)
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Anti-Cancer, Cytotoxic drugs (Oncology)
Indication: Doxorubicin is an anthracycline type of chemotherapy that is used to treat several different types of cancer. Doxorubicin works by slowing or stopping the growth of cancer cells.
Storage:Store at a temperature not exceeding 30°C. Protect from light. Do not freeze.

GENERIC NAME OF MEDICINAL PRODUCT:

  • Doxorubicin Hydrochloride Injection BP 50mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Doxorubicin Hydrochloride Injection BP 50mg
    Each Vial contains:
    Doxorubicin Hydrochloride BP……….50mg
    Excipients…………………………………………q. s

THERAPEUTIC INDICATION:

Doxorubicin is also indicated for the treatment of cancers of the ovary, prostate, stomach, and thyroid; small cell cancer of the lung, and liver; squamous cell cancer of the head and neck; multiple myeloma, Hodgkin’s disease, lymphomas, acute lymphocytic leukemia (ALL), and acute myeloid leukemia (AML).

DIRECTION OF USE:

To be reconstituted with 25ml or 5ml by adding Sterile Water for Injection BP or 0.9% Sodium Chloride or 5% Dextrose in Sterile Water for Injection to give final concentration of 2mg/ml.
After reconstitution the solution is stable for 7 days at room temperature and 15 days at 2°C to 8°C.
Use immediately after reconstitution.

CAUTION & Warning:

CAUTION: Do not use the injection if the contents are not clear or contains visible particulate matter after reconstitution.
CYTOTOXIX-DISPOSE OF PROPERLY
Do not pool unused portion from the vials. Do not administer more than one dose from a vial.
Warning: Cytotoxic agent: Not to be sold by retail without the prescription of a Registered Medical Practitioner/ Cancer Hospital only.
It is dangerous to take this preparation except under Medical Supervision.

STORAGE & DOSAGE:

Storage: Store at a temperature not exceeding 30°C. Protect from light. Do not freeze.
Please refer product insert for more information.
KEEP MEDICINE OUT OF REACH OF CHILDREN.
FLIP-OFF SEAL IS PROVIDED FOR TEMPER EVIDENCE
Dosage: As directed by an Oncologist.

Why Taj Pharmaceutical?

Taj Pharmaceuticals Limited, a distinguished name in the pharmaceutical industry, presents Doxorubicin Hydrochloride for Injection 50mg, a significant advancement in cancer therapy. With a steadfast focus on innovation, quality, and patient well-being, Taj Pharma has developed this chemotherapy medication as a potent weapon against various types of cancer. Doxorubicin Hydrochloride for Injection 50mg is a testament to Taj Pharmaceuticals’ commitment to delivering effective healthcare solutions. This formulation encapsulates the power of Doxorubicin, a cytotoxic agent known for its ability to disrupt the growth and proliferation of cancer cells by interfering with their DNA structure.

Taj Pharma’s dedication to precision is evident in the meticulous design of this injection. It is meticulously formulated to be administered under the guidance of healthcare professionals in controlled medical settings. Through rigorous quality control measures, Taj Pharmaceuticals ensures that each dose meets the highest standards of safety and efficacy. Moreover, Taj Pharmaceuticals Limited’s legacy of excellence encompasses a patient-centric approach. The development of Doxorubicin Hydrochloride for Injection 50mg underscores the company’s commitment to positively impacting the lives of individuals fighting cancer. This medication is a manifestation of Taj Pharma’s continuous efforts to improve healthcare outcomes and enhance the quality of life for patients worldwide.

What is Doxorubicin Hydrochloride for Injection BP 50mg?

Doxorubicin Hydrochloride for Injection BP 50mg is a pharmaceutical product used in the treatment of various types of cancer. It is a chemotherapy medication designed to target and combat cancer cells within the body. Doxorubicin Hydrochloride, the active ingredient in this injection, is a potent cytotoxic agent. It works by interfering with the DNA of cancer cells, disrupting their ability to divide and multiply. This action ultimately leads to the suppression of cancer cell growth and a reduction in tumor size.

Doxorubicin Hydrochloride for Injection BP 50mg is administered via injection by healthcare professionals. The dosage and administration are determined based on the specific type of cancer being treated, the patient’s medical history, and the treatment plan devised by the medical team. It’s important to note that this medication is typically used as part of a comprehensive cancer treatment strategy, which may include surgery, radiation therapy, and other therapies. The decision to use Doxorubicin Hydrochloride for Injection BP 50mg is made by medical professionals based on the individual patient’s condition and treatment needs.

Benefits of Doxorubicin Hydrochloride for Injection BP 50mg:

Doxorubicin Hydrochloride for Injection BP 50mg offers several benefits in the treatment of cancer:

  • Effective Cancer Treatment: Doxorubicin is a potent chemotherapy medication known for its ability to target and destroy cancer cells. It is used in the treatment of various types of cancer, including breast cancer, lung cancer, and certain types of leukemia and lymphoma.
  • Tumor Reduction: By disrupting the DNA within cancer cells, Doxorubicin inhibits their ability to divide and grow. This can lead to the shrinkage of tumors and the potential relief of cancer-related symptoms.
  • Adjuvant and Neoadjuvant Therapy: Doxorubicin is often used in combination with other treatments. It can be employed as adjuvant therapy after surgery to reduce the risk of cancer recurrence, or as neoadjuvant therapy before surgery to shrink tumors and facilitate surgical removal.
  • Broad Applicability: Due to its effectiveness against a wide range of cancers, Doxorubicin Hydrochloride is a versatile treatment option that has shown positive outcomes in different cancer types.

Side Effects of Doxorubicin Hydrochloride for Injection BP 50mg:

Doxorubicin can also cause several side effects, which can vary from person to person. Some potential side effects include:

  • Nausea and Vomiting: These are common side effects of chemotherapy. Anti-nausea medications can often help manage these symptoms.
  • Hair Loss: Doxorubicin can cause hair loss, although hair usually grows back after treatment ends.
  • Fatigue: Cancer treatments can lead to fatigue, ranging from mild to severe.
  • Myelosuppression: Doxorubicin affects bone marrow, leading to reduced blood cell counts. This can result in anemia (low red blood cells), increased infection risk (low white blood cells), and increased bleeding risk (low platelets).
  • Cardiac Effects: Doxorubicin can have toxic effects on the heart, potentially leading to heart damage. Regular monitoring of heart function is crucial during treatment.
  • Gastrointestinal Issues: Diarrhea, mouth sores, and loss of appetite can occur.
  • Skin Changes: Some patients may experience changes in skin color or rash.
  • Long-Term Effects: Doxorubicin can have potential long-term effects on the heart, especially with high cumulative doses over time.

Uses of Doxorubicin Hydrochloride for Injection BP 50mg:

Doxorubicin Hydrochloride for Injection BP 50mg is a chemotherapy medication with versatile applications in the treatment of various types of cancer. Some of its primary uses include:

  • Breast Cancer: Doxorubicin is often used in the treatment of both early-stage and advanced breast cancer. It can be part of neoadjuvant therapy to shrink tumors before surgery or adjuvant therapy to reduce the risk of recurrence after surgery.
  • Lung Cancer: Doxorubicin is utilized in the treatment of certain types of lung cancer, including small cell lung cancer and non-small cell lung cancer.
  • Ovarian Cancer: It is used as part of the treatment regimen for ovarian cancer, either alone or in combination with other chemotherapy drugs.
  • Soft Tissue Sarcomas: Doxorubicin is effective in treating soft tissue sarcomas, a group of cancers that develop in the soft tissues of the body, such as muscles, tendons, and fat.
  • Hodgkin’s Lymphoma: Doxorubicin is a component of chemotherapy regimens for Hodgkin’s lymphoma, a type of lymphatic system cancer.
  • Non-Hodgkin’s Lymphoma: It is used in certain cases of non-Hodgkin’s lymphoma, another type of lymphatic system cancer.
  • Leukaemia: Doxorubicin can be employed in the treatment of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
  • Bladder Cancer: Doxorubicin might be used to treat advanced bladder cancer, especially when other treatments have not been effective.
  • Stomach Cancer: It can be included in chemotherapy regimens for advanced stomach (gastric) cancer.
  • Other Cancers: Doxorubicin might also be considered for certain other cancers, depending on the specific case and the recommendations of the medical team.

How Does Doxorubicin Hydrochloride for Injection Work:

  • Interference with DNA Replication:
    Doxorubicin Hydrochloride for Injection operates as an anthracycline chemotherapy agent. When introduced into the bloodstream, it travels to the site of cancer cells. Inside these cells, Doxorubicin intercalates itself between the base pairs of DNA. This intercalation disrupts the structure of DNA strands, preventing the normal unwinding and replication process during cell division.
  • DNA Damage and Impaired Repair:
    Doxorubicin doesn’t just inhibit DNA replication, but it also induces breaks in the DNA strands. The damage inflicted on the DNA triggers a cellular response, activating DNA repair mechanisms. However, the cumulative and extensive DNA damage caused by Doxorubicin overwhelms the cell’s repair capacity. This compromises the integrity of the genetic material within the cancer cell.
  • Inhibition of Topoisomerase II:
    Doxorubicin also interferes with enzymes known as topoisomerases, particularly topoisomerase II. These enzymes are crucial for maintaining DNA structure during cell division. Doxorubicin binds to topoisomerase II and prevents it from resealing DNA strands after they’ve been unwound. This results in further DNA breaks and structural abnormalities.
  • Triggering Apoptosis:
    The cumulative damage inflicted by Doxorubicin on the DNA reaches a point where the cancer cell’s survival mechanisms are overwhelmed. At this juncture, the cell activates a controlled self-destruct mechanism known as apoptosis. Apoptosis ensures that damaged cells are removed from the body in a controlled manner, preventing them from further proliferation.
  • Selective Impact on Rapidly Dividing Cells:
    One of the reasons Doxorubicin is effective against cancer cells is that it targets rapidly dividing cells, a characteristic of cancer growth. Cancer cells divide more frequently than healthy cells, making them more susceptible to the disruptions caused by Doxorubicin. However, it’s important to note that some healthy cells in the body, such as those in the bone marrow and digestive tract, also divide rapidly, which can lead to side effects.

Frequently asked questions about Doxorubicin Hydrochloride for Injection:

Certainly, here are some frequently asked questions (FAQs) about Doxorubicin Hydrochloride for Injection:

What is Doxorubicin Hydrochloride for Injection?

Doxorubicin Hydrochloride for Injection is a chemotherapy medication used in the treatment of various types of cancer. It works by interfering with the DNA of cancer cells, inhibiting their growth and replication.

How is Doxorubicin administered?

Doxorubicin is typically administered as an intravenous (IV) injection by a healthcare professional in a hospital or clinic setting.

What types of cancer is Doxorubicin used to treat?

Doxorubicin is used in the treatment of breast cancer, lung cancer, ovarian cancer, soft tissue sarcomas, lymphomas, leukemias, and other types of cancer.

How does Doxorubicin work?

Doxorubicin disrupts the DNA replication and repair processes within cancer cells. This disruption leads to cellular damage and ultimately triggers the cancer cells to undergo programmed cell death (apoptosis).

What are the potential benefits of using Doxorubicin Hydrochloride for Injection?

Doxorubicin can shrink tumors, reduce the risk of cancer recurrence, and improve survival rates in some cases. It’s a valuable tool in cancer treatment.

What are the common side effects of Doxorubicin?

Common side effects can include nausea, vomiting, fatigue, hair loss, and decreased blood cell counts. It can also affect the heart and lead to potential long-term cardiac effects.

Is Doxorubicin used alone or in combination with other drugs?

Doxorubicin can be used as a single agent or in combination with other chemotherapy drugs, depending on the specific cancer and treatment plan.

How often will I receive Doxorubicin injections?

The frequency and dosage of Doxorubicin injections depend on the type of cancer being treated, the patient’s medical condition, and the treatment plan. Your healthcare provider will determine the appropriate schedule.

Can Doxorubicin interact with other medications?

Yes, Doxorubicin can interact with certain medications, so it’s important to inform your healthcare provider about all the medications, supplements, and herbs you are taking.

How is my treatment progress monitored during Doxorubicin therapy?

Your healthcare team will regularly monitor your response to treatment through various tests, including blood tests and imaging studies. This helps ensure the effectiveness of the treatment and manage any potential side effects.

As Doxorubicin Hydrochloride for Injection BP 50 mg Exporters; We can cater to export business queries from the following geographies. We are exporting our Doxorubicin Hydrochloride for Injection BP 50 mg product in Following Countries

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Doxorubicin Hydrochloride for Injection BP 50 mg Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Get in touch with Taj Pharmaceuticals Limited, the most dependable producer of Doxorubicin Hydrochloride for Injection BP 50 mg, to procure large quantities at an affordable cost.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274